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Injectafer and Venofer are both brand-name drugs. You may report side effects to the FDA at 1-800-332-1088. Consult the product instructions and your pharmacist for storage details. Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. How is Venofer (iron sucrose) given? Below are examples of these side effects. <> But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. And this over-activation is what may lead to an allergic reaction or a delayed allergic reaction. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Venofer is not for treating other forms of anemia not caused by iron deficiency. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Always review your medical history with the treatingphysician. Procedure Details Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. "That's why it's so . fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). A shortage of iron can cause health problems. Other drugs are available that can treat iron deficiency anemia (IDA). For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. The potential side effects of Daxxify are nearly identical to that of Botox bruising, headaches, and droopy eyelids with one big difference: They could last longer. Keep out of reach of children. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Weight changes may be due to symptoms of anemia improving. Severeside effectsmay end up causing a lot of disruption in a persons life. Heart failure: Could a low sodium diet sometimes do more harm than good? Injectafer contains the active drug ferric carboxymaltose. Since side effects are similar between 150 mg and 300 mg, a larger dose may increase severity or frequency of side effects. In Canada - Call your doctor for medical advice about side effects. For example, if someone takes 100 mg of a drug, only half of it will be in the bloodstream in a couple ofhours. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. In the first group, some people continued taking iron by mouth, while other people took Injectafer. endobj However, some people can experienceside effectsfor much longer - days, months, or indefinitely. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. fever. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. I'm contemplating getting infusions again but I've always been a bit worried that they could cause issues in the long run. If administering via IV infusion, up to 750 mg of Injectafer should be diluted in no more than 250 mL of sterile 0.9% sodium chloride solution (NaCl). You may report side effects to FDA at 1-800-FDA-1088. After getting one treatment course of Injectafer, you typically wont need another dose of the drug again unless your anemia comes back. But its not known whether this poses any risk to a child whos breastfed. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. If you have questions about using Injectafer for anemia during pregnancy, talk with your doctor. Both Injectafer and Venofer belong to a class of medications called iron replacement products. This is why the FDA hasa programcalledMedWatchthat encourages Americans to report adversereactions. 5 0 obj I had my first infusion of 1gm 10 days ago. Dizziness. Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. Evenbirth controlcan lead to severeside effectslike bloodclots. Your doctor will do laboratory tests to monitor your response. Examples of thisinclude: Not allside effectslast forever. Feraheme is also approved to treat IDA in adults who either didnt have improvement in their IDA or had side effects with iron treatment thats taken by mouth. Injectafer can cause mild or serious side effects. Find out what health conditions may be a health risk when taken with Venofer Vial If you have questions about side effects, call your doctor. Taking a larger dose of LSD can extend the duration of the trip, but generally, the main effects of LSD don't tend to last any longer than 12 hours. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. This document does not contain all possible drug interactions. One class of immune checkpoint inhibitors targets the protein PD-1, which acts as a brake to keep the immune system in check. Injectafer comes as a liquid thats given by either intravenous (IV) infusion or slow IV injection. (And Injectafer is used to treat IDA.) Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. Call your doctor right away if you have serious side effects. These drugs have been compared in a clinical trial of adults with both IDA and CKD who didnt need dialysis. Injectafer infusions are given over a period of at least 15 minutes. You may report side effects to FDA at 1-800-FDA-1088. However, to be safe, tell your doctor or pharmacist about all prescription, over-the-counter, and other drugs you take before taking Injectafer. Side effects are uncomfortable reactions to medications or drugs. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. This website is intended for use by US healthcare professionals only. Iron is an essential nutrient needed to maintain energy levels and keep you healthy. On day three I had a headache and felt heavy/exhausted, which lasted a few days. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). Many patients with kidney disease cannot get enough iron from food and require injections. Dr. Brandon ColbyMDis a US physician specializingin the personalized prevention of disease through the use of genomic technologies. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. If youre wondering how longside effectslast, youll be happy to know they can last just a few hours. Its responsible for carrying oxygen throughout your body. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. weakness. You may also need to monitor your blood pressure at home. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. Do not start, stop, or change the dose of any drug without checking with your doctor. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. Youll receive doses of either drug by a healthcare professional at a medical facility. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Venofer may cause significant hypotension (decreased blood pressure). Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Hemoglobin is a protein thats found in your RBCs. Check with your pharmacist if you have questions about the best way to throw out drugs. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. Phosphorus is an electrolyte that your body needs in order to make energy. Change in taste. I was surprised too but the Dr said it definitely sounds like a reaction. If youre taking iron pills, be sure to tell your doctor before starting Injectafer. (One treatment course includes two doses of the drug.) (Hemoglobin is a protein thats found in red blood cells.). In stock alternatives of Venofer (based on Iron Sucrose ) Orofer S 200 Injection 1 Injection in 1 Packet 540 569 5% off. Keep all medications away from children and pets. Low iron saturation, or iron deficiency, has various possible causes. Brandon ColbyMD, a medical expert specializing in preventive medicine and clinicalgenomics. These side effects may include constipation and diarrhea. (See also Notes section.). Instead, youll start by receiving just one treatment course of Injectafer. Serious side effects should be reported to a physician and/or PharmD for medical advice. You will be watched closely for at least 30 minutes to make sure you do not have an allergic reaction. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. Severeside effectscan lead to injury or death -drowsinesscan cause a car accident or injury when operating heavymachinery. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Venofer may reduce the absorption of iron preparations taken by mouth. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. Back pain. And these two doses need to be separated by at least 7 days. Common Venofer side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting, diarrhea; muscle or joint pain, back pain; pain or swelling in an arm or leg; itching; or bruising or irritation where the medicine was injected. These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). For people with certain medical implants, such as pacemakers, an MRI may pose an . Side effects from HRT depend on a number of factors: Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Once inside your body, ferric carboxymaltose releases iron into your system. Excessive amounts of Venofer may lead to a condition called iron overload, which may be harmful. Sharing this information can help you avoid potential interactions. Side effects like nausea and low blood pressure are common with most iron infusions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Data on file, American Regent, Inc. 1. Call your doctor for medical advice about side effects. Nose or throat irritation. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. This is not a list of all drugs or health problems that interact with this medicine. With slow IV injection, the drug is given as a single, slow injection into your vein. Infusion times range from less than 20 minutes to up to 4 hours. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Tell your doctor about the allergy and what signs you had. (A generic drug is an exact copy of the active drug in a brand-name medication.). Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. Cardiovascular health: Insomnia linked to greater risk of heart attack. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. These are not all of the side effects that may occur. This medication passes into breast milk. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. Others last much longer (even a lifetime), which can be quite traumatizing to people. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Answer by DrLact: About Venofer usage in lactation. You may report side effects to the FDA at 1-800-332-1088. Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. (A medication class describes a group of drugs that work in the same way.). Mental healthdisorders like depression may requireantidepressantsto treat. Most of these side effects may go away within a few days or a couple of weeks. However, many people have no side effects or only have minor side effects. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Consult your doctor before breast-feeding. other treatments you receive, you will need to go back for several treatments with Venofer. Cancer patients who have anemia and are taking an ESA. Call your doctor for instructions if you miss an appointment for your Venofer injection. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. Also tell them about any vitamins, herbs, and supplements you use. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. Injectafer should be stored between 68F to 77F (20C to 25C). Feraheme also comes as a liquid thats given by IV infusion. (IV iron is absorbed by the body more rapidly than oral iron.) Yes, in some cases it may. What are the side effects of Venofer? This site is intended for use only by US patients. If you have symptoms of a low phosphorus level, call your doctor. But so far I feel better than before the infusion. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. If you notice any changes to your normal blood pressure, call your doctor right away. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. Iron infusion side effects vary depending on which form is being used. And this can lead to anemia, including IDA. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. Call your doctor right away if youre having a severe allergic reaction to Injectafer, even if youve had doses of the drug in the past without any problems. This medication is given by injection into a vein as directed by your doctor. You should not receive Venofer if you have ever had an allergic reaction to an iron injection, or if you have iron overload (the buildup of excess iron) or hemochromatosis. These lists dont include all possible side effects. With this condition, you also have a low hemoglobin level. The rest of the people switched from taking iron by mouth to taking an iron product other than Injectafer thats given by IV. So you wont pick up this medication from a pharmacy. signs of inflammation in the lining of your stomach - pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. Why is the range so wide? Source: Wolters Kluwer Health. These include: Note: For more information about the potential negative effects of Injectafer, see the Injectafer side effects section above. <> This is not a complete list of side effects and others may occur. Many people using this medication do not have serious side effects. Together, they can recommend ways to help you manage a body weight thats healthy for you. Innovators Monograph Use of the term female in this article refers to sex assigned at birth. Is the ketogenic diet right for autoimmune conditions? If these effects continue or worsen, tell your doctor. Precautions. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Its not known whether its safe to breastfeed while youre taking Injectafer. Injectafer comes as a liquid solution inside vials. Effectiveness of Injectafer compared with iron thats taken by mouth. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. It's a more immediate treatment than supplements or dietary changes. Its not currently available in generic form. You should always consult your doctor or another healthcare professional before taking any medication. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. I got Venofer twice in the last few years and now my iron deficiency is worse than ever, first time my hemoglobin is down to 11,2. Do not double the dose to catch up. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. But you dont necessarily need to eat these foods unless your doctor tells you to do so. Its not known if Injectafer is safe to take during pregnancy. FG Trade/E+ sia Getty Images Version: 7.01. Check with your pharmacist. Here are answers to some frequently asked questions about Injectafer. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. Tell all of your health care providers that you take Venofer. Youll receive doses of Injectafer from a healthcare professional at a medical facility. pain in the arms or legs. Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. For instance, those who are taking other medications or supplements as part of home remedies may continue to suffer from the ill effects of their new medication because they dontinteract. Serious side effects from Injectafer arent common, but they can occur. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes discharge or excessive tearing This includes people who: Usually, hypophosphatemia doesnt cause symptoms. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. For more information about Injectafers approved uses, see the section Injectafer uses below. These changes could help improve your anemia on a long-term basis. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.