Kletzmayr J, Mayer G, Legenstein E, et al. Nutr J 2012;11:52. Broad, E. M., Maughan, R. J., and Galloway S DR. Prev Nutr Food Sci 2020;25(2):124-32. View abstract. View abstract. View abstract. (20,39) Common causes of insomnia include stress, an irregular sleep schedule, poor sleeping habits, mental health disorders like anxiety and depression, physical illnesses and pain, medications . Turpeinen, A. K., Kuikka, J. T., Vanninen, E., Yang, J., and Uusitupa, M. I. Megri K, Trombert JC Zannier A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Improved pallesthetic sensitivity of pudendal nerve in impotent diabetic patients treated with acetyl-L-carnitine. View abstract. 1995;146(12):769-774. 2005;28(2):141-152. Muscle carnitine deficiency in patients using valproic acid. Drugs Exp Clin Res 1992;18(2):69-80. 2011;(12):CD006282. View abstract. Novak M, Monkus EF, Buch M, and et al. Report of one case]. A pilot study on aging skeletal muscle mass and function. Cochrane.Database.Syst.Rev. Lion's mane mushrooms may offer a number of health benefits. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. View abstract. 2017;96(39):e8117 View abstract. J Clin Endocrinol Metab 2001;86:3579-94. Int Urol Nephrol 2021;53(10):2149-2158. [RETRACTED]. L-carnitine might increase the effects of acenocoumarol and increase the chance of bruising and bleeding. Research suggests that L-carnitine may aid exercise performance and treat health conditions like heart disease and type 2 diabetes. View abstract. View abstract. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. View abstract. Carnitine deficiency disorders in children. Kidney Int 1990;38:912-8. Hiraoka A, Kiguchi D, Ninomiya T, et al. See our dietitian's picks for women. JPEN J Parenter.Enteral Nutr 1990;14(5):448-453. View abstract. Sima AAF, Calvani M, Mehra M, et al. Amelioration of the depression of HIV-infected subjects with L-acetyl carnitine therapy. High levels of TMAO are linked to an increased risk of atherosclerosis a disease which clogs your arteries (59, 60). Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. View abstract. Endocr J 2018;65(5):521-6. [L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. Cardiovasc.Drugs Ther 2012;26(5):401-408. Suchitra, M. M., Ashalatha, V. L., Sailaja, E., Rao, A. M., Reddy, V. S., Bitla, A. R., Sivakumar, V., and Rao, P. V. The effect of L-carnitine supplementation on lipid parameters, inflammatory and nutritional markers in maintenance hemodialysis patients. Genazzani, A. D., Lanzoni, C., Ricchieri, F., Santagni, S., Rattighieri, E., Chierchia, E., Monteleone, P., and Jasonni, V. M. Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. Effect of propionyl-L-carnitine on quality of life in intermittent claudication. View abstract. As with any supplement, you should speak with your doctor before taking L-carnitine. Exp.Physiol 2008;93(10):1139-1146. J Assoc Physicians India 2000;48(11):1050-1052. 7-14-2009;89(26):1858-1861. Quality of life during and between hemodialysis treatments: role of L- carnitine supplementation. Effect of L-carnitine supplementation on acute valproate intoxication. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Cochrane.Database.Syst.Rev. Curr Ther res, Clin exp 1982;32(11):116-127. Clin Neuropharmacol. L-Carnitine as a diet supplement in patients with type II diabetes. Written by Cerner Multum. Brevetti, G., Attisano, T., Perna, S., Rossini, A., Policicchio, A., and Corsi, M. Effect of L-carnitine on the reactive hyperemia in patients affected by peripheral vascular disease: a double-blind, crossover study. Spiekerkoetter, U., Lindner, M., Santer, R., Grotzke, M., Baumgartner, M. R., Boehles, H., Das, A., Haase, C., Hennermann, J. Fagher, B., Thysell, H., Nilsson-Ehle, P., Monti, M., Olsson, L., Eriksson, M., Lindstedt, S., and Lindholm, T. The effect of D,L-carnitine supplementation on muscle metabolism, neuropathy, cardiac and hepatic function in hemodialysis patients. Protective effect of intravenous levocarnitine on subsequent-month hospitalization among prevalent hemodialysis patients, 1998 to 2003. Zhao, J. L., Gao, D. Z., Liu, D., He, H. H., She, Q., and Yin, Y. H. Improvement of exercise tolerance by L-carnitine in patients with cardiac syndrome X. Chin.Hosp.Pharm.J. Loffredo, L., Pignatelli, P., Cangemi, R., Andreozzi, P., Panico, M. A., Meloni, V., and Violi, F. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. Propionyl-l-carnitine: Uses, Side Effects, Dose, Health Benefits View abstract. In an eight-week study in 38 women who exercised four times per week, there was no difference in weight loss between those who took L-carnitine and those who didnt (24). View abstract. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Nihon Rinsho 2007;65(6):1005-1010. Clin Exp.Rheumatol. 2009;48(5):587-596. L-carnitine is best known as a fat burner but the overall research is mixed. An analysis of 3 multicenter studies and a bibliographic review]. A., Flory, J., Rowan, C. G., and Brunelli, S. M. Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E. Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. J Pain Symptom Manage 2006;32:551-9. Endocr J. Ann N.Y.Acad.Sci 2004;1033:168-176. Sheida A, Davar R, Tabibnejad N, Eftekhar M. The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial. Penn, D., Schmidt-Sommerfeld, E., and Pascu, F. Decreased tissue carnitine concentrations in newborn infants receiving total parenteral nutrition. It also caused me to urinate a lot. BMC Public Health. A. View abstract. Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., Nakai, S., Miwa, M., Morita, H., Miwa, T., Amano, I., and Maeda, K. Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. The effect of enteral carnitine administration in humans. View abstract. View abstract. G Ital Cardiol 1983;13(11):291-294. Metabolic rates vary by individual. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Sotobatake I, Noda S, Hayashi H, and et al. Zelnik N, Fridkis I, Gruener N. Reduced carnitine and antiepileptic drugs: cause relationship or co-existence? L-Carnitine Benefits, Side Effects & Dosage - SelfHacked Metabolism 2010;59(8):1190-1199. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Nutrients 2018;10(2). Acetyl-L-Carnitine - WebMD Pediatrics 1994;93:893-5. Caponnetto S, Canale C, Masperone MA, et al. 2005;59(4):592-596. View abstract. Immunopharmacol.Immunotoxicol. Heart complications (such as irregular heartbeat and heart failure). 2010;15(2):200-211. Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. Ann.Saudi.Med. Am.J Kidney Dis 1999;34(4):678-687. Are There Side Effects to L-Carnitine Supplementation? Be sure to have your blood checked regularly. Prohaska ES, Muzyk AJ, Rivelli SK. View abstract. Casciani, C. U., Caruso, U., Cravotto, E., Corsi, M., Pola, P., Savi, L., and Grilli, M. Effect of L-carnitine on lipid pattern in haemodialysis. L-Carnitine Benefits Endurance, Fat Burning and Brain Function The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study. 2011;31(2):125-132. Ann.Clin Psychiatry 2009;21(4):213-236. 2008;107(2):139-144. 2019;14(6):504-514. Eur J Heart Fail. Z. Zanardi, R. and Smeraldi, E. A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. Romano, M., Vacante, M., Cristaldi, E., Colonna, V., Gargante, M. P., Cammalleri, L., and Malaguarnera, M. L-carnitine treatment reduces steatosis in patients with chronic hepatitis C treated with alpha-interferon and ribavirin. 2007;22(5):727-733. View abstract. Exp.Diabetes Res. Anxiety (feeling nervous and jittery). Pacheco, A., Torres, R., Sanhueza, M. E., Elgueta, L., Segovia, E., and Cano, M. [Study of aerobic capacity in chronic hemodialized patients: effect of L-carnitine supplementation]. Ellaway, C. J., Peat, J., Williams, K., Leonard, H., and Christodoulou, J. Medium-term open label trial of L-carnitine in Rett syndrome. Clin Ther 2010;32(4):710-713. The dose of your acenocoumarol might need to be changed. Epilepsia 1993;34:184-7. Eur J Gastroenterol Hepatol 2019;31(7):878-84. doi: 10.1097/MEG.0000000000001368. View abstract. Acta Chir Scand Suppl 1983;517:157-164. View abstract. Toptas, B., Baykal, A., Yesilipek, A., Isbir, M., Kupesiz, A., Yalcin, O., and Baskurt, O. K. L-carnitine deficiency and red blood cell mechanical impairment in beta-thalassemia major. It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina). Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. One 12-month study observed a reduction in heart failure and deaths among participants who took L-carnitine supplements (42). View abstract. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. L-Carnosine and Autism | Nutrition Review Arch.Pharm Res 2012;35(11):1945-1952. View abstract. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Carnitine supplement benefit and side effects, dosage of 250 mg, 500 mg Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sun, Z. J., Yang, C. B., Wang, H., and Li, Y. Clin Drug Investig. Hiatt WR, Regensteiner JG, Creager MA, et al. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. View abstract. View abstract. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. 2006;115(1-2):91-96. View abstract. Sum CF, Winocour PH, Agius L, and et al. De Vecchi, A. F., Arduini, A., Di, Liberato L., and Bonomini, M. [L-carnitine in peritoneal dialysis]. Sohn HJ, Choi GB Yoon KI. View abstract. Russell, S. Carnitine as an antidote for acute valproate toxicity in children. Diabetes Res.Clin Pract. Kimmoun, A., Munagamage, G., Dessalles, N., Gerard, A., Feillet, F., and Levy, B. Neuropsychobiology 1997;35:16-23. Proc Assoc Am Physicians 1997;109:146-53. View abstract. View abstract. JPEN J Parenter.Enteral Nutr. Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. J Am Soc Nephrol 2002;13:708-14.. View abstract. Ann.Pharmacother. View abstract. Chinese J.Clin.Healthcare 2008;11(5):478-480. Br J Cancer 2002;86:1854-7. A. Effects of parenteral L-carnitine supplementation on fat metabolism and nutrition in premature neonates. I. Carnitine concentrations and lipid effects." J Huazhong.Univ Sci Technolog.Med.Sci 2006;26(2):188-191. View abstract. View abstract. Maestri, A., De Pasquale, Ceratti A., Cundari, S., Zanna, C., Cortesi, E., and Crino, L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy.