Elsevier; 2021. https://www.clinicalkey.com. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Please note that only the generic name of each medication is listed below. This makes it easier for your heart to pump, relieving heart-related chest pain. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . Accessed Sept. 7, 2022. FOIA Last Revised - 09/15/2019. Prices for isosorbide mononitrate (Monoket) start at just $29.86 with a GoodRx coupon. An official website of the United States government. To provide you with the most relevant and helpful information, and understand which Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty Ask your pharmacist for a list of the ingredients. You may opt-out of email communications at any time by clicking on Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). It is unknown if this medication passes into breast milk. Use this medication regularly to get the most benefit from it. This medicine is for you. Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Take isosorbide exactly as directed. Licorice. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. https://naturalmedicines.therapeuticresearch.com. Isosorbide mononitrate belongs to the group of medicines called nitrates. Egton Medical Information Systems Limited. During pregnancy, this medication should be used only when clearly needed. Isosorbide mononitrate helps to prevent angina chest pain from developing. If you are a Mayo Clinic patient, this could 2017; doi:10.1016/j.jacc.2016.11.078. MeSH View interaction reports for isosorbide mononitrate and the medicines listed below. Reduction of blood-nitrate concentrations to low levels for 4 to 12 hours each day usually maintains effectiveness in such patients. Please enable it to take advantage of the complete set of features! Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Integrative medicine (complementary and alternative medicine). Isosorbide mononitrate has an average rating of https://naturalmedicines.therapeuticresearch.com. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. sharing sensitive information, make sure youre on a federal Would you like email updates of new search results? You can develop a tolerance to isosorbide mononitrate (Monoket) over time, which means the dose you've been taking doesn't work as well. Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . This is called a medicine interaction. Call your doctor for medical advice about side effects. Can cause dizziness, especially when you change positions, Interacts with erectile dysfunction medications. Clipboard, Search History, and several other advanced features are temporarily unavailable. Contraindications: Isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e.g following a head trauma and including cerebral haemorrhage. Is not subject to the Controlled Substances Act. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Longer-acting tablets and capsules are taken once daily in the morning. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. Murray MT. We comply with the HONcode standard for trustworthy health information. Accessed Sept. 7, 2022. Your dose may need to be gradually decreased. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Click here for an email preview. It can cause your blood pressure to become dangerously low. This content does not have an English version. information highlighted below and resubmit the form. Danshen. The extended-release tablet usually is taken once daily in the morning. Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, isosorbide mononitrate consumer information. Take extra precautions to avoid falling during your treatment with isosorbide. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking isosorbide. Natural Medicines. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Side effects : headache, mild dizziness Portions of this document last updated: Feb. 01, 2023. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. Does Viagra add to the risks of melanoma? Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). Higher dosages are associated with stomach irritation and But only about 25% of people who take herbal supplements tell their health care providers. It is in the nitrate class of drugs. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Conclusions: prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. Talk to your pharmacist for more details. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. There may be variations in CSA schedules between individual states. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Consult your doctor for more details. Normal ecg doesn't rule out heart disease. Isosorbide mononitrate (Monoket) is a nitrate vasodilator. Talk to your provider if you notice your chest pain starts to get worse. To help you remember, take it at the same times each day. For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). Patient is a UK registered trade mark. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. May also be prescribed off label for Esophageal Spasm. Isosorbide Mononitrate - Uses, Side Effects, and More - WebMD This content does not have an Arabic version. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Natural Medicines. This risk may be even higher for certain groups. Don't drink alcohol while taking isosorbide mononitrate (Monoket). Do not keep out-of-date or unwanted medicines. https://naturalmedicines.therapeuticresearch.com. In the US - Call your doctor for medical advice about side effects. Do not change the dosing times unless directed by your doctor. . You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. Call your doctor if you have any unusual problems while you are taking this medication. Review/update the May also be prescribed off label for Esophageal Spasm. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). The extended-release capsule usually is taken once daily. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. View all Natural Medicines. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. Available for Android and iOS devices. Before By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Eur Heart J. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Isosorbide Mononitrate - Uses, Side Effects, Substitutes, Composition Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Herbal supplements are natural, so they must be safe, right? Seek alternatives to the CYP3A4 substrate when possible. it is a safe and effective alternative; the choice between beta blockers and calcium channel blockers depends . Generic alternatives may be available. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. I took this for 4 days, and my headaches were unbearable. Other side effects not listed may also occur in some patients. All rights reserved. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. If you have ever had an allergic reaction to a medicine. AHFS Patient Medication Information. The most common side-effect is headache. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Federal government websites often end in .gov or .mil. This information is aggregated and used to produce personalized reports that patients can reference. In: Current Medical Diagnosis & Treatment 2022. This survey is being conducted by the WebMD marketing sciences department. If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate. Registered in England and Wales. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Alcohol or marijuana (cannabis) can make you more dizzy. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Glyceryl trinitrate (GTN) is commonly prescribed for this. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. Unauthorized use of these marks is strictly prohibited. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. health information, we will treat all of that information as protected health Accessed Sept. 7, 2022. Cardizem Alternatives Compared - Drugs.com Natural Medicines. Nitroglycerin works very quickly to widen your blood vessels and help your heart pump blood during a heart attack. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Isosorbide mononitrate works in two ways. Drug information provided by: IBM Micromedex. the unsubscribe link in the e-mail. See also: aspirin side effects in more detail. 1998 Oct;61(10):577-83. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Take the container with you, even if it is empty. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . 5.0 out of 10 from a total of https://naturalmedicines.therapeuticresearch.com. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. If you have recently had a head injury or a heart attack. It can cause your blood pressure to become dangerously low. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. GoodRx works to make its website accessible to all, including those with disabilities. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Real test is coronary angiography. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. You can consult me online for homeopathic treatment. Always consult your healthcare provider. Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). You may report side effects to Health Canada at 1-866-234-2345. Generic alternatives may be available. Unless there is a specific reason you need the brand, the generic medication will be a better value. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. Methods: Does Isosorbide Mononitrate interact with other drugs you are taking? The information on this page is written and peer reviewed by qualified clinicians. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. Accessed Sept. 7, 2022. Store it at room temperature and away from excess heat and moisture (not in the bathroom). other information we have about you. Nitrates in the management of acute coronary syndrome. Diabetes treatment: Can cinnamon lower blood sugar? Natural Medicines. This product may contain inactive ingredients, which can cause allergic reactions or other problems. This document does not contain all possible drug interactions. It works to relax your blood vessels. Get emergency help immediately if any of the following symptoms of overdose occur: bulging soft spot on the head of an infant, change in the ability to see colors, especially blue or yellow, feeling of constant movement of self or surroundings. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. That's why you need to talk with your health care provider before you take herbal supplements if you take prescription medicines. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.