Anthracycline cardiotoxicity prevention lotrisone

/Subtype /Link /Subtype /Link These include early initiation of medications (e.g., angiotensin-converting enzyme inhibitors, β-blockers) to prevent the progression from asymptomatic to symptomatic disease.Aggressive management of comorbidities such as hypertension and diabetes may be the most practical approach to reducing long-term CHF risk, but there is a paucity of information on optimal strategies for screening and intervention in at-risk survivors. Ivabradine to Prevent Anthracycline-induced Cardiotoxicity (IPAC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Studies are currently under way to test risk-reducing strategies. /ColorSpace 34 0 R 14 0 obj >> /Type /Annot Anthracyclines, such as doxorubicin or epirubicin, have been used for decades for the treatment of a variety of cancers, including breast cancer, sarcoma, lymphoma, and leukemia. /Subtype /Link /Subtype /Link /Dest (�� b i b 1 4) /Border [0 0 0] /Subtype /Link 1 Type I cardiotoxicity is a known irreversible complication of anthracycline use and is associated with cumulative doses (Table 1). 19 0 obj endobj /Rect [165.883 324.17 180.283 331.88] :bqضx��d�2��fݼ]�ZYN(s�_Nڇy��A�q.K 21 0 obj >> Listing a study does not mean it has been evaluated by the U.S. Federal Government. /Type /Annot Cardiotoxicity Anthracycline cardiotoxic effects were unrecognized until 1967 when Karnofsky et al. /Rect [260.05 240.435 301.493 248.201] h��{[��H�^�~ӯ�ˉ 7D��8��jcF�#��1{ ݍޖ��z��s��,d7�=�~t(BM u��Û]=��Fn��^��7��/��t�u��ϣ_�=�_��nt��?�E*��4��Ϫ�l��S��8>L�\��/>��݋{��?f2��rZz_�nZeu>*J?-˼]-�5mo^L�,��d>��x�M�d7.��K��\�t�0u�z�l��,�d�6]�1�z{��[��v�_�hO��c��y��2�;Nc��&��ζȱ��;죵7��_�Q�:qӐ��- �� $ ��u�y��Ty2�g��,6�Y;a;{��g << /Type /Annot Approach to prevention — Optimum preventive management of cardiotoxicity requires a multidisciplinary approach with close collaboration between the treating oncologist, internist, and cardiologist. /Subtype /Link /Border [0 0 0] endobj "�/��B�`]�A��v�X�t3�_0xA%��-��m3W��_�;=ƾL�+� ��8�� s�W�f,�o�p��wJ�}�|\��gE��f�)D��"x��r�g�F��Z�� << A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicinClinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up studyClinical cardiotoxicity following anthracycline treatment for childhood cancer: the Pediatric Oncology Group experienceChronic health conditions in adult survivors of childhood cancerRole of cancer treatment in long-term overall and cardiovascular mortality after childhood cancerChronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemiaCardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohortModifiable risk factors and major cardiac events among adult survivors of childhood cancerCardiovascular morbidity in long-term survivors of early-onset cancer: a population-based studyAssociation of anthracycline-related cardiac histological lesions with NADPH oxidase functional polymorphismsUnderlying causes and long-term survival in patients with initially unexplained cardiomyopathyCardiac function in 5-year survivors of childhood cancer: a long-term follow-up studyLong-term cardiac and pulmonary complications of cancer therapyPathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and preventionAnthracycline-induced cardiotoxicity in children and young adultsAnthracycline cardiotoxicity in long-term survivors of childhood cancer2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the International Society for Heart and Lung TransplantationHypertension in long-term survivors of childhood cancer: a nested case-control studyCardiovascular risk factors in adult survivors of pediatric cancer--a report from the childhood cancer survivor studyDiabetes mellitus in long-term survivors of childhood cancer. 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