The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Single-dose combination antihypertension therapy is an important option that combines efficacy of blood pressure reduction and a low side effect profile with convenient once-daily dosing to enhance compliance. A large multicenter study. Coulson LR, These effects lead to decreased sodium retention and an enhanced antihypertensive effect.Synergism between ACE inhibitors and diuretics is especially prominent in black patients, a population in whom monotherapy with ACE inhibitors has been shown to be less effective than it is in white patients. Gilmore HR, Gragnani S, Diuretic regimens in essential hypertension. Okun R, Treatment adherence: mean % proportion of days covered (PDC) for antihypertensive drug combinations of interest. Whelton P, Despite extensive debate about the first choice for treating essential hypertension, monotherapy effectively normalizes blood pressure (BP) values in only a limited number of hypertensive patients. Unable to load your collection due to an error Antihypertensive drugs can be effectively combined if they have different and complementary mechanisms of action. Hollenberg NK, Trandolapril Study Group. Combination antihypertensives include combined agents from the following pharmacologic classes: diuretics and potassium-sparing diuretics, beta blockers and diuretics, angiotensin-converting enzyme (ACE) inhibitors and diuretics, angiotensin-II antagonists and diuretics, and calcium channel blockers and ACE inhibitors. Although calcium antagonists exert much of their antihypertensive effect through a vasodilatory action, they also have diuretic and natriuretic properties.ACE inhibitors and calcium channel blockers work effectively in combination to lower blood pressure.Calcium antagonists and ACE inhibitors may also work together to favorably influence target-organ disease independent of their effect on blood pressure. Other techniques which have been used as an embryo interspecies natl acad sci u s a embryonic stem cells in glioblastoma 13 glioblastoma-derived cancer stem cells. Multicenter Diuretic Cooperative Study Group. Psaty BM, Holland OB. Weiss NS, Clipboard, Search History, and several other advanced features are temporarily unavailable. Smith NL, Suxamethonium the prototype aminoglycoside was streptomycin, which u common adverse effects obstruction. Antihypertensive effectiveness of low-dose lisinopril-hydrochlorothiazide combination. Antihypertensive effectiveness of low-dose lisinopril-hydrochlorothiazide combination. A multifactorial trial design to assess combination therapy in hypertension. Siscovick DS, COVID-19 is an emerging, rapidly evolving situation. Neutel JM, Dr. Skolnik graduated from Emory University School of Medicine, Atlanta, and completed a family practice residency at Jefferson Medical College of Thomas Jefferson University, Philadelphia.JONATHAN D. BECK, M.D., is a third-year resident and chief resident in the family practice residency program at Abington Memorial Hospital. Weber MA. Moser M, A comparison of six antihypertensive agents with placebo. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI)Although the documented decreases in morbidity and mortality make adequate treatment of hypertension important, the National Health and Nutrition Examination Survey (NHANES) reportThe rationale for using fixed-dose combination therapy is to obtain increased blood pressure control by employing two antihypertensive agents with different modes of action and to enhance compliance by using a single tablet that is taken once or twice daily.Spironolactone and hydrochlorothiazide (25 mg/50 mg, 50 mg/50 mg)Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 50 mg/25 mg)Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 75 mg/50 mg)Atenolol and chlorthalidone (50 mg/25 mg, 100 mg/25 mg)Bisoprolol and hydrochlorothiazide (2.5 mg/6.25 mg, 5 mg/6.25 mg, 10 mg/6.5 mg)Metoprolol and hydrochlorothiazide (50 mg/25 mg, 100 mg/25 mg, 100 mg/50 mg)Nadolol and bendroflumethazide (40 mg/5 mg, 80 mg/5 mg)Propranolol and hydrochlorothiazide (40 mg/25 mg, 80 mg/25 mg)Propranolol ER and hydrochlorothiazide (80 mg/50 mg, 120 mg/50 mg, 160 mg/50 mg)Benazepril and hydrochlorothiazide (5 mg/6.25 mg, 10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Captopril and hydrochlorothiazide (25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, 50 mg/25 mg)Enalapril and hydrochlorothiazide (5 mg/12.5 mg, 10 mg/25 mg)Lisinopril and hydrochlorothiazide (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Lisinopril and hydrochlorothiazide (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Moexipril and hydrochlorothiazide (7.5 mg/12.5 mg, 15 mg/25 mg)Losartan and hydrochlorothiazide (50 mg/12.5 mg, 100 mg/25 mg)Valsartan and hydrochlorothiazide (80 mg/12.5 mg, 160 mg/12.5 mg)Amlodipine and benazepril (2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg)Verapamil and trandolapril (180 mg/2 mg, 240 mg/1 mg, 240 mg/2 mg, 240 mg/4 mg)Clonidine and chlorthalidone (0.1 mg/15 mg, 0.2 mg/15 mg, 0.3 mg/15 mg)Hydralazine and hydrochlorothiazide (25 mg/25 mg, 50 mg/50 mg, 100 mg/50 mg)Methyldopa and hydrochlorothiazide (250 mg/15 mg, 250 mg/25 mg, 500 mg/30 mg, 500 mg/50 mg)Prazosin and polythiazide (1 mg/0.5 mg, 2 mg/0.5 mg, 5 mg/0.5 mg)Spironolactone and hydrochlorothiazide (25 mg/50 mg, 50 mg/50 mg)Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 50 mg/25 mg)Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 75 mg/50 mg)Atenolol and chlorthalidone (50 mg/25 mg, 100 mg/25 mg)Bisoprolol and hydrochlorothiazide (2.5 mg/6.25 mg, 5 mg/6.25 mg, 10 mg/6.5 mg)Metoprolol and hydrochlorothiazide (50 mg/25 mg, 100 mg/25 mg, 100 mg/50 mg)Nadolol and bendroflumethazide (40 mg/5 mg, 80 mg/5 mg)Propranolol and hydrochlorothiazide (40 mg/25 mg, 80 mg/25 mg)Propranolol ER and hydrochlorothiazide (80 mg/50 mg, 120 mg/50 mg, 160 mg/50 mg)Benazepril and hydrochlorothiazide (5 mg/6.25 mg, 10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Captopril and hydrochlorothiazide (25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, 50 mg/25 mg)Enalapril and hydrochlorothiazide (5 mg/12.5 mg, 10 mg/25 mg)Lisinopril and hydrochlorothiazide (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Lisinopril and hydrochlorothiazide (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg)Moexipril and hydrochlorothiazide (7.5 mg/12.5 mg, 15 mg/25 mg)Losartan and hydrochlorothiazide (50 mg/12.5 mg, 100 mg/25 mg)Valsartan and hydrochlorothiazide (80 mg/12.5 mg, 160 mg/12.5 mg)Amlodipine and benazepril (2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg)Verapamil and trandolapril (180 mg/2 mg, 240 mg/1 mg, 240 mg/2 mg, 240 mg/4 mg)Clonidine and chlorthalidone (0.1 mg/15 mg, 0.2 mg/15 mg, 0.3 mg/15 mg)Hydralazine and hydrochlorothiazide (25 mg/25 mg, 50 mg/50 mg, 100 mg/50 mg)Methyldopa and hydrochlorothiazide (250 mg/15 mg, 250 mg/25 mg, 500 mg/30 mg, 500 mg/50 mg)Prazosin and polythiazide (1 mg/0.5 mg, 2 mg/0.5 mg, 5 mg/0.5 mg)Diuretics are effective antihypertensive drugs. 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