The Cochrane database of systematic reviews. Compare Clindamycin vs Vancomycin head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, et al. Inclusion of women who delivered by caesarean section and received prophylactic antibiotics varied between trials. One study was a multi-centre study conducted in many countries including the USA.Clinical criteria used to define endometritis were consistent across trials and included fever and uterine tenderness. Maternal infections around childbirth also have a considerable impact on newborn mortality, and an estimated 1 million newborn deaths are associated with such infections annually. Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The guideline will also be useful to...This document is part of the process for improving the quality of care in family planning. Results with clindamycin and gentamicin were excellent and were attributed primarily to the activity of clindamycin against anaerobes, particularly Bacteroides fragilis. Serum concentrations of clindamycin surpassed by manyfold the minimal inhibitory concentrations (MICs) for anaerobes. Gentamicin is injected into a muscle, or into a vein through an IV. In the majority of studies that demonstrated benefits of clindamycin and gentamicin over other regimens, clindamycin was administered as 600 mg IV every six to eight hours, and gentamicin was administered as 1–1.5 mg/kg or 60–80 mg IV or IM every eight hours. 2015.9. Results with clindamycin and gentamicin were excellent and were attributed primarily to the activity of clindamycin against anaerobes, particularly Fass RJ, Ruiz DE, Gardner WG, Rotilie CA. Some trials also considered pelvic pain, purulent lochia, parametrial tenderness, leucocytosis, absence of other foci of infection or, in contrast, included women with chorioamnionitis or salpingitis or pelvic cellulitis after caesarean section. The Lancet Global health. 4 million neonatal deaths: When?
2015(2):Cd001067.WHO recommendation on a combination of clindamycin and gentamicin for the treatment of postpartum endometritis (September 2015). A combination of clindamycin and gentamicin is recommended for the treatment of postpartum endometritis.Bacterial infections during labour and the puerperium are among the leading causes of maternal mortality worldwide, accounting for about one tenth of the global burden of maternal deaths. If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. (5, 6) In addition, infection-related morbidities and prolonged hospitalization can interfere with mother–infant bonding in the first days after birth.The recommendation was developed using standardized operating procedures in accordance with the process described in the “WHO handbook for guideline development”, guided by the GRADE approach. GDG members discussed the balance between desirable and undesirable effects, overall quality of supporting evidence, values and preferences of stakeholders, resource requirements, cost-effectiveness, acceptability, feasibility and equity, to formulate the recommendation. (3) Although the reported incidence in high-income countries is relatively low (between 0.1 and 0.6 per 1000 births), it is nonetheless an important direct cause of maternal mortality. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) … (7) Outcomes used for this recommendation were aligned with the prioritized outcomes from the WHO recommendations on prevention and treatment of maternal peripartum infections (2015). For anaerobes and outcome L, Gulmezoglu AM, van Roosmalen J. maternal sepsis: epidemiology etiology... An IV at home a, Drife J, Garrod D, et.! Was conducted on the breastfed infant 's gastrointestinal flora RE, Ota E, Speer L. 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