My white blood cell count is below 500. But a number of conditions, including liver disease and some cancers, can cause your spleen to enlarge.Thrombocytopenia means you have fewer than 150,000 platelets per microliter of circulating blood. Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B. Paroxetine decreases platelet serotonin storage and platelet function in human beings. It affects both children and adults.Thrombocytopenia can be mild and cause few signs or symptoms. SSRIs decrease an important platelet component called serotonin, which may cause bleeding in some patients. Low platelet count, or thrombocytopenia, is a lower than normal number of platelets, i.e. For patients at high risk of abnormal bleeding, consider prescribing an antidepressant with low serotonin reuptake inhibition, which may lower risk. Treatment options are available.Petechiae may look like a rash and usually appear in clusters. SSRIs, which are known to decrease platelet serotonin content, have been reported to be associated with bleeding in a minority of patients and recently have been associated with an increase in gastrointestinal bleeding. Even though platelet numbers are decreased in thrombocytopenia, their function generally remains completely intact. Seek immediate help for bleeding that can't be controlled by the usual first-aid techniques, such as applying pressure to the area.The spleen is a small organ normally about the size of your fist. The purpose of this study is to better understand the potential risks of bleeding associated with mild platelet dysfunction in patients using SSRIs and to determine whether a global test of platelet function, as performed on the platelet function analyzer-100, is able to identify the changes in platelet function associated with SSRI use. The analysis will include a statistical comparison of the platelet function in patients on SSRIs with those on a non-SSRI antidepressant medication (bupropion). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The results of the SSRI-treated group and the bupropion-treated group will be analyzed and compared.This study may provide information that will help health care providers make treatment decisions to minimize possible adverse effects of medications in patients with depression.Male or female subjects with a diagnosis of depression over the age of 18 years,Subjects currently prescribed and taking a stable dose of SSRI for at least 6 weeks, orSubjects currently prescribed and taking a stable dose of bupropion for at least 6 weeks.Inherited or acquired coagulopathies or platelet disordersAbnormal thyroid function (TSH less than 0.42 or greater than 4.4 micro IU/ml and free T4 less than 1.0 or greater than 1.9 ng/dL).Severe depression as indicated by the following: Major depressive disorder single episode, severe without psychotic features DSM-IV 296.23; Major depressive disorder single episode, severe with psychotic features DSM-IV 296.24; Major depressive disorder recurrent, severe without psychotic features DSM-IV 296.33; Major depressive disorder recurrent, severe with psychotic features DSM-IV 296.34.Patients who are currently receiving coumadin or heparin, non-steroidal antiinflammatory drugs (NSAIDs), acetylsalicylic acid (Aspirin), corticosteroids, chemotherapy, or other medications known to interfere with platelet function studies will not be eligible.Patients taking NSAIDS and aspirin or other medications known to interfere with platelet function studies will be eligible if they discontinue these medications for more than 10 days prior to testing.Patients who are taking the following psychotropic medications: valproic acid, carbamazepine, buspiron, atypical antipsychotics, or any other psychotropic medications will not be eligible. The study takes about 1 hour. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Subjects will be recruited from a private clinic in Washington, D.C.Participants will provide a history of their current medications and past history of bleeding. Practice recommendations . In addition, low grade fever and muscle aches may occur. Clin Pharmacol Ther 2000;68:435-442. What can I … A low platelet count can make it difficult for the blood to clot, putting a person at risk of excessive bleeding. Whatever the cause, circulating platelets are reduced by one or more of the following processes: trapping of platelets in the spleen, decreased platelet production or increased destruction of platelets.The spleen is a small organ about the size of your fist situated just below your rib cage on the left side of your abdomen. The patients will be selected from a private clinic in the Washington, DC, area and will undergo a baseline assessment (history of bleeding and/or thrombosis), blood tests for routine blood counts, chemistries, and platelet function using the PFA-100. Thrombocytopenia is a condition in which you have a low blood platelet count. Dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets per microliter. Complications. Drug interactions of Bactrim include warfarin, because Bactrim enhances its blood-thinning effects, possibly leading to bleeding. Because each platelet lives only about 10 days, your body normally renews your platelet supply continually by producing new platelets in your bone marrow.Thrombocytopenia rarely is inherited; or it can be caused by a number of medications or conditions.