Despite these general reservations about using the label ‘ototoxic’ rather freely, it is clear that several classes of drugs do damage the inner ear. Consult your Are you planning to see a doctor about switching your medication?Are you planning to see a doctor about switching your medication?Selected from data included with permission and copyrighted by First Databank, Inc. Epidemiological data suggest that there may be an association between the use of carbamazepine during pregnancy and congenital malformations, including spina bifida. Use The chewable tablets or suspension may contain sugar. These reactions can happen in anyone, but are more likely in people of Asian descent. There is no specific antidote.Gastric lavage. The risk of developing SIADH with carbamazepine treatment appears to be dose-related. The significance of these findings relative to the use of carbamazepine in humans is, at present, unknown.Because of the potential for serious adverse reactions in nursing infants from carbamazepine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.Taken as a whole, this information supports a conclusion that the generally accepted therapeutic range of total carbamazepine in plasma (i.e. The name or look may be different in other countries. Bacterial and mammalian mutagenicity studies using carbamazepine produced negative results. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6 PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. In children, the dosage is also based their Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. In dogs, it produced a brownish discoloration, presumably a metabolite, in the urinary bladder at dosage levels of 50 mg/kg and higher. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.Stopping carbamazepine extended-release tablets suddenly can cause serious problems.Call your healthcare provider right away if you have any of the following:Stopping carbamazepine extended-release tablets suddenly can cause serious problems. There have also been reports that associate carbamazepine with developmental disorders and congenital anomalies (e.g., craniofacial defects, cardiovascular malformations, and anomalies involving various body systems). Carbamazepine extended-release tablets may cause allergic reactions or serious problems, which may affect organs and other parts of your body like the liver or blood cells. Discontinuation of the drug should be considered if any evidence of significant bone marrow depression develops.Baseline and periodic evaluations of liver function, particularly in patients with a history of liver disease, must be performed during treatment with this drug since liver damage may occur (see Baseline and periodic eye examinations, including slit-lamp, funduscopy, and tonometry, are recommended since many phenothiazines and related drugs have been shown to cause eye changes.Baseline and periodic complete urinalysis and BUN determinations are recommended for patients treated with this agent because of observed renal dysfunction.Thyroid function tests have been reported to show decreased values with carbamazepine administered alone.Interference with some pregnancy tests has been reported.Clinically meaningful drug interactions have occurred with concomitant medications and include (but are not limited to) the following:CYP3A4 inhibitors inhibit carbamazepine metabolism and can thus increase plasma carbamazepine levels.