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There was little or no systemic accumulation of clindamycin after repeated vaginal dosing of clindamycin phosphate vaginal cream 2%. Topical clindamycin may also be used for other problems as determined by your doctor. (See The recommended dose is one applicatorful of clindamycin phosphate vaginal cream USP, 2%, (5 grams containing approximately 100 mg of clindamycin phosphate) intravaginally, preferably at bedtime, for 3 or 7 consecutive days in non-pregnant patients and for 7 consecutive days in pregnant patients. Carefully withdraw applicator from vagina, and discard applicator.REMEMBER TO APPLY ONE APPLICATORFUL EACH NIGHT BEFORE BEDTIME, OR AS PRESCRIBED BY YOUR DOCTOR. 482 0 obj
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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. The determination of clinical cure was based on the absence of a "fishy" amine odor when the vaginal discharge was mixed with a 10% KOH solution and the absence of clue cells on microscopic examination.7 Disposable plastic applicators are provided with this package. It is used on the skin to stop the growth of certain bacteria that cause acne. Call your doctor for medical advice about side effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Clindamycin belongs to the family of medicines called antibiotics. Topical clindamycin is used to help control acne. (See Thirty patients with recurrent suppurative hidradenitis entered a double blind trial to evaluate the effect of topical clindamycin against placebo in hidradenitis. (See Clindamycin phosphate vaginal cream USP, 2%, is indicated in the treatment of bacterial vaginosis (formerly referred to as Other pathogens commonly associated with vulvovaginitis, eg, Clindamycin phosphate vaginal cream 2%, is contraindicated in individuals with a history of hypersensitivity to clindamycin, lincomycin, or any of the components of this vaginal cream. It is used on the skin to stop the growth of certain bacteria that cause acne. Clindamycin is … Other reported clinical experience has not identified differences in responses between the elderly and younger patients.Other events occurring in <1% of the clindamycin vaginal cream 2% groups include:Other events occurring in <1% of the clindamycin vaginal cream 2% group include:Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.In the post-marketing period, there have been case reports of psueodmembranous colitis with the use of clindamycin phosphate vaginal cream.Clindamycin vaginal cream affords minimal peak serum levels and systemic exposure (AUCs) of clindamycin compared to 100 mg oral clindamycin dosing. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Mild cases of pseudomembranous colitis usually respond to discontinuation of the drug alone. Therefore, use of such products within 72 hours following treatment with clindamycin phosphate vaginal cream 2%, is not recommended. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.
Select one or more newsletters to continue. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Find user ratings and reviews for clindamycin phosphate topical on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction 448 0 obj
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Clindamycin Phosphate is a topical antibiotic used to treat mild to severely inflamed acne. These peak concentrations were attained approximately 14 hours post-dosing (range 4 to 24 hours). 464 0 obj
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Clindamycin phosphate vaginal cream USP, 2%, can be used to treat non-pregnant women and pregnant women during the second and third trimester. Ask your doctor or pharmacist if you do not understand these instructions.Wash your hands before and after applying this medicine.Call your doctor if your symptoms do not improve, or if they get worse.If you need surgery, tell your surgeon you currently use this medicine. Topical medicine is for use only on the skin. It is used on the skin to stop the growth of certain bacteria that cause acne. Fertility studies in rats treated orally with up to 300 mg/kg/day (31 times the human exposure based on mg/mIn clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters, has not been associated with an increased frequency of congenital abnormalities.Clindamycin vaginal cream should be used during the first trimester of pregnancy only if clearly needed and the benefits outweigh the risks.