Its cytotoxic effect is mainly due to cross-linking of strands of DNA and RNA, and to inhibition of protein synthesis. Mechanisms of Action [MoA] - Alkylating Activity: Pharmacological Classes: Established Pharmacologic Class [EPC] - Alkylating Drug : FDA Pharmacology Summary: Cyclophosphamide anhydrous is an Alkylating Drug. ROCALTROL® (calcitriol) Capsules And Oral Solution. Help. Thus, an early inflammatory and destructive phase followed by a synthetic and proliferative phase with type II pneumocyte proliferation is believed to occur (CTX is frequently used to treat malignant lymphomas, Hodgkin’s disease, lymphocytic lymphoma, mixed-cell type lymphoma, histocytic lymphoma, Burkitt’s lymphoma, multiple myeloma, and several types of leukemias, including chronic lymphocytic, chronic granulocytic, acute myelogenous, monocytic leukemia, and acute lymphoblastic (stem-cell) leukemia in children (NCI Bioportal). Cyclophosphamide is a drug that is used primarily for treating several types of cancer.In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. Present in the blood, it is practically inactive, although upon penetrating cancerous cells This means that the alkylating action of this drug is specifically directed toward cancerous cells. Mechanisms of Action [MoA] - Alkylating Activity: Pharmacological Classes: Established Pharmacologic Class [EPC] - Alkylating Drug : FDA Pharmacology Summary: Cyclophosphamide anhydrous is an Alkylating Drug. L - Antineoplastic and immunomodulating … Yes, it is. Alkylating agents have … Cyclophosphamide Mechanism of Action. These metabolites appear to play a role in cyclophosphamide-induced pulmonary toxicity by disrupting the lipid bilayer and initiating peroxidative damage, type I pneumocyte injury, increased intra-alveolar fibrinous exudation, and a systemic inflammatory response. Rodents are injected intraperitoneally with either a single dose of 150 mg/kg or two doses (150 and 100 mg/kg) spread over two days.Medication used as chemotherapy and to suppress the immune systemInChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12) What it is used for. Thus, based on this list of malignancies, which includes all of the major immune cell types, this agent has major immunotoxic effects, especially at high doses.The actions of CTX show bimodal dose dependency. Cyclophosphamide is a cytotoxic (cytostatic), cell cycle nonspecific, antiproliferative agent which is used in such diverse medical problems as neoplasia, tissue transplantation and inflammatory diseases.In a mouse model of sarcoma using photodynamic therapy (PDT) and cyclophosphamide, PDT alone led to tumor regression but no permanent survival (In agreement with this, low doses of cyclophosphamide selectively decreased Tregs in patients with various tumor types and improved T cell and NK cell function, while higher doses depleted all T cells and decreased T cell- and NK cell-mediated immunity (The reliance of cyclophosphamide upon metabolism in order to generate the desired cytotoxic species In contrast to the aforementioned nitrogen mustard-based agents, cyclophosphamide shows reduced reports of nonhematopoetic toxicity. View Patient Info Sheet. Do you know that cancer tumors are formed by uncontrolled growth of unwanted cells? Thus, based on this list of malignancies, which includes all of the major immune cell types, this agent has major immunotoxic effects, especially at high doses.The actions of CTX show bimodal dose dependency. These metabolites appear to play a role in cyclophosphamide-induced pulmonary toxicity by disrupting the lipid bilayer and initiating peroxidative damage, type I pneumocyte injury, increased intra-alveolar fibrinous exudation, and a systemic inflammatory response. At higher doses, it interrupts cell cycle by forming DNA cross linking, DNA lesions. Early studies on the effects of CTX on immune elements demonstrated that low doses of CTX had substantially different effects compared to high doses.