Epilepsy Res 2001 Nov;47(1-2):151-4. Maybe your neuro has some insights?Wow - that's a great article. My docs were at a loss & so was I until I read your posts. The biggest change I have noticed is that I am more feminine. AED treatment can alter the levels of different sex hormones. We want to stay connected with you.Im 26 and I've been on 200mg of lamictal for a mood disorder for about a year now. While you may not be bipolar, it does help some people with their depression. Over the past year I have experienced terrible night sweets and have been told by my doc that it wasn't a SE of Lamictal. But after a while I started having vaginitis which my OB/GYN said is due to low estrogen levels. I know that studies showed that Lamictal reduces the levels of synthetic estrogen in people taking hormonal birth control, so I'm guessing it has similar effects on natural estrogen too. I never brought it up before because it didn't occur to me that my low estrogen was related to Lamictal. Epilepsy Res 2001 Nov;47(1-2):151-4. I didn't go through it thoroughly yet, but it may be helpful.I also have PCOS, but no hot flashes, etc. With the exception of possible weight loss, none of these were included in the medication's listed side effects and my doctor insisted that none of it had anything to do with the lamictal. Due to the popularity of social media, we have seen decreasing engagement on our forums and chat. I though that something might be wrong with my thyroid (which was checked and no problems). Thanks!Hi, I'm new but I really want to respond because I've been having similar problems. This mechanism appears to be caused by the induction of lamotrigine glucuronidation by OCs.Practitioners have known for almost 2 decades that oral contraceptives consistently and substantially reduce the serum concentrations of lamotrigine and may reduce seizure control./publications/issue/2018/November2018/estrogens-and-lamotrigine-new-developments2 Clarke Drive Suite 100 Cranbury, NJ 08512 P:609-716-7777 F:609-716-9038 Over time, this elevation can lead to lower levels of bioactive testosterone and estradiol, which may cause menstrual disturbances, sexual problems, and eventually reduced fertility. Lamotrigine plasma levels reduced by oral contraceptives. I don't know for sure if lamictal messes with hormones although I've read that it does mess with birth control pills. EIAEDs increase sex hormone binding globulin (SHBG) concentrations in both men and women. The first side effect I noticed was that my breasts were getting smaller, then my hair was thinning and my periods were becoming lighter and irregular and I couldn't stop losing weight. A little old at this point, but pretty well written and sited! so I'm thinking reduced estrogen has something to do with it.It's interesting that you're having low-estrogen trouble as well, and I really think Lamictal could be causing it based on my own experience and information I've managed to find. Hopefully he'll have some answers. The woman may therefore need to lower her dose of lamotrigine. I'd really appreciate hearing from anyone who has had similar problems, or has any knowledge of how lamictal might affect estrogen levels. So it's possible that lamictal can be interfering with your body producing it's natural amount of estrogen. 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