Elsevier Science The sterility of the solutions was confirmed by culturing sample from each lot. Aims and Objectives: The aim was to determine which patient groups (age, diagnosis) receive inhalation therapy with 3% HS and what clinical benefit can be achieved. Thank you for submitting a comment on this article. Hypertonic saline is an inhaled sterile salt solution, which has a higher concentration of salt than blood plasma and may be effective in non-CF bronchiectasis airway clearance.. Do not save for future use. The Ethics Committee of AIIMS approved the study. 2013 Jul 31;(7):CD006458. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Name must be less than 100 characters Please enable it to take advantage of the complete set of features! The trial was registered with the Clinical Trials Registry-India (CTRI/2010/091/001279).Children between the ages of 6 and 16 years, diagnosed with cystic fibrosis, on regular follow up for at least past 12 months, who were able to perform reproducible pulmonary function test, were eligible for the study. Objective: To determine the utility of inhaled hypertonic saline solution to treat infants hospitalized with viral bronchiolitis. Routine medications were continued throughout the study.All enrolled patients were followed up for 4 weeks (follow-up visits on Day 14 and 28). There is a need for studies with larger sample size and longer duration to establish the comparability of effects of various concentrations of hypertonic saline and the potential side effects of higher concentrations of hypertonic saline.We acknowledge Baxter Pharmaceuticals Limited for providing technical assistance for preparing the study drugs.Oxford University Press is a department of the University of Oxford. Eng Most of the studies have compared varying concentration of hypertonic saline with isotonic saline and hypertonic saline has been documented to be more efficacious than isotonic saline [Worldwide, varying concentration of hypertonic saline are used for their mucociliary clearance-enhancing properties; however, the benefits of using higher concentration of hypertonic saline are not well explored. Your comment will be reviewed and published at the journal's discretion. However, the mean reduction in FEV 1 after 7% saline was 3.6% at baseline and 1.07% on Day 28.. Functional capacity. Design: Randomized, double-blind, controlled trial. Respiratory manifestations are the major cause of morbidity and mortality [A double-blind randomized, controlled trial was conducted in the Pediatric Chest Clinic of All India Institute of Medical Sciences (AIIMS), New Delhi, India. On each visit, clinical details were recorded, spirometry and 3-min step test [Subjects were asked to return all unused containers of the saline solution and to maintain a diary to record the treatment doses taken to assess adherence to the treatment.PEFR was measured using a Wright’s Peak flow meter. Unable to load your collection due to an error This site needs JavaScript to work properly. There were insignificant changes in all the variables in both the groups. Elsevier Science Discard any unused solution. 2017 Nov;11(6):525-530. doi: 10.1111/irv.12503. Pediculosis Affects Mexican Children from Different Socioeconomic Status Equally: A Cross-Sectional Study
The VAS showed small insignificant improvements from 0.61 to 0.27 cm and from 0.31 to 0.3 cm in 3 and 7% hypertonic saline groups, respectively. Clinical Features and Outcome of SARS-CoV-2 Infection in Neonates: A Systematic Review
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The mean ranks of 15-count score of the two groups were comparable on all contact days with no significant difference.We planned this study to examine whether 3 and 7% saline inhalation provided similar improvement in the pulmonary function of children with cystic fibrosis. eCollection 2015.Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP.Cochrane Database Syst Rev. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.