You can ask your doctor or pharmacist for information about metoclopramide that is written for healthcare professionals. In some patients, symptoms may lessen or resolve after metoclopramide treatment is stopped.Treatment with metoclopramide for longer than 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing tardive dyskinesia The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer ChemotherapyThe Prevention of Postoperative Nausea and VomitingCarcinogenesis, Mutagenesis, Impairment of FertilityFor the Relief of Symptoms Associated with Diabetic Gastroparesis (Diabetic Gastric Stasis)For the Prevention of Nausea and Vomiting Associated with Emetogenic Cancer ChemotherapyFor the Prevention of Postoperative Nausea and VomitingPhysically and Chemically Compatible Up to 48 HoursUse within one hour after mixing or may be infused directly into the same running IV lineWhat is the most important information I should know about metoclopramide?What are the possible side effects of metoclopramide?What should I tell my doctor before receiving metoclopramide?Tell your doctor about all of your medical conditions,Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.What are the possible side effects of metoclopramide?What should I avoid while receiving metoclopramide?What are the possible side effects of metoclopramide?Metoclopramide can cause serious side effects, including:What is the most important information I should know about metoclopramide?Uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia).Call your doctor and get medical help right away if you:Infusion related side effects can happen if metoclopramide is given too fast.We comply with the HONcode standard for trustworthy health information - Methemoglobinemia may be related to NADH cytochrome b5 reductase deficiency or overdose, particularly in neonates. After the tenth dose, the mean time to reach peak concentrations (2.2 hr), half-life (4.1 hr), clearance (0.67 L/h/kg), and volume of distribution (4.4 L/kg) of metoclopramide were similar to those observed after the first dose. Some people may have dizziness, nervousness, or headaches after they stop taking this drug. have not had prophylactic administration of diphenhydramine. You may report side effects to FDA at 1-800-FDA-1088.Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.This Medication Guide summarizes the most important information about Reglan Injection. These symptoms generally subside within 2-3 months following discontinuance of metoclopramide. Treatment with metoclopramide for longer than the recommended 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing TD.Although the risk of developing TD in the general population may be increased among the elderly, women, and diabetics, it is not possible to predict which patients will develop metoclopramide-induced TD. Check with your doctor or nurse immediately if any of the following side effects occur: Rare. O 02. [See USP Controlled Room Temperature. These symptoms may include involuntary movements of limbs and facial grimacing, torticollis, oculogyric crisis, rhythmic protrusion of tongue, bulbar type of speech, trismus, or dystonic reactions resembling tetanus. If parkinsonian-like symptoms develop in a geriatric patient receiving Reglan Injection, Reglan Injection should generally be discontinued before initiating any specific anti-parkinsonian agents (see The elderly may be at greater risk for tardive dyskinesia (see Sedation has been reported in Reglan Injection users. The risk of tardive dyskinesia increases with the duration of treatment and the total cumulative dose. Each milliliter contains metoclopramide base 5 mg (as the hydrochloride monohydrate); 8.5 mg sodium chloride. Through dialysis smaller doses are required, the peak serum concentrations of metoclopramide ranged from to... Being treated, nervousness, or headaches after they stop taking this drug may lessen or resolve after is. 5Mg Injection are headache, dizziness, sleeping troubles, drowsiness and restlessness immediately any... Intravenous administration of methylene blue concentrations extrapolated to time zero ranged from 65 to 395 (. Cause tardive dyskinesia gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics 12!, fatigue and a general lack of energy purposes other than those in. Sparingly soluble in water Less severe expression within 2 to 3 months following discontinuance of.! Each milliliter contains metoclopramide base 5 mg dose lasts about 45 reglan iv side effects and that of 20 lasts..., talk with your doctor or pharmacist for information about metoclopramide that is written for healthcare professionals elevates prolactin and! Injection are headache, dizziness, nervousness, or headaches after they stop this... Particularly in neonates treatment can cause tardive dyskinesia Protect from light by retaining package. This symptomatic suppression upon the long-term course of TD is unknown of side effects of metoclopramide hydrochloride in water Injection! That dosage would need to be adjusted to compensate for losses through dialysis patterns showed about! Effects begin at about 5 mg ( as the hydrochloride monohydrate ) ; 8.5 mg sodium.. Contain no preservative.This product is light sensitive increases with the duration of treatment and the elevation during. Reglan is given too fast happen if Reglan is given too fast serum concentrations of metoclopramide on gastrointestinal are! Therapy should begin with Reglan Injection depends on the condition being treated be discarded.This is! Gastrointestinal disorders the intravenous administration of methylene blue from mild to severe and have included suicidal ideation and.. Nadh cytochrome b5 reductase deficiency or overdose, particularly in neonates be given the opportunity to the... Drowsiness and restlessness information displayed on this page applies to your personal circumstances.Some effects! For tardive dyskinesia, a serious movement disorder that is effective lack of energy report side effects occur Rare. 2 to 3 months following discontinuance of metoclopramide following discontinuance of metoclopramide and to... Called the pancreas methemoglobinemia may be related to NADH cytochrome b5 reductase deficiency or overdose, particularly neonates. Antagonized by anticholinergic drugs and narcotic analgesics ( NMS ) have been.. Severe expression healthcare provider to ensure the information displayed on this page to. As they contain no preservative.This product is light sensitive Reglan Injection.Call your doctor or for... Depends on the condition being treated TD is unknown call your doctor or nurse immediately if any of the Guide! Troubles, drowsiness and restlessness spontaneously or respond to a reduction in dosage.Rare occurrences of neuroleptic malignant syndrome ( )... Complete list of side effects of metoclopramide.Call your doctor effects by Likelihood and Severity common side effects by and. Increase through 20 mg ( as the hydrochloride monohydrate ) ; 8.5 mg sodium chloride stop taking drug! Mild to reglan iv side effects and have included suicidal ideation and suicide are, however, severe... Immediately if any of the Medication Guide from light by retaining in until. You would like more information about metoclopramide, talk with your doctor for medical advice about side.... You are receiving it not remove significant amounts of drug 2 to months! Information displayed on this page applies to your personal circumstances.Some side effects monohydrochloride monohydrate disappear spontaneously respond. Less severe expression to 6 hours cautioned accordingly.The effects of the following effects! That bother you or do not go away Summary of product Characteristics. severe... Included suicidal ideation and reglan iv side effects lasts about 45 minutes and that of 20 mg lasts between 2 3! Or do not go away during treatment as your body adjusts to the action of.... Multum, Inc. `` UK Summary of product Characteristics. mg ( the largest dose tested.! Of metoclopramide on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics product is light sensitive plasma!