Epub 2018 Feb 2. Finally, they measured the levels of oestradiol in the blood.Statistical tests were used to compare the average results across the groups. Please enable it to take advantage of the complete set of features! // Leaf Group Lifestyle Estrogen is one of the sex hormones that is responsible for women's reproduction abilities. The loss of that interaction leads to the clinical signs of dryness and wrinkling,” says Dr. Berson, who presented “A New Cosmeceutical for Estrogen Deficient Skin” at the American Academy of Dermatology’s (AAD) … 2005 Oct;53(4):555-68; quiz 569-72. doi: 10.1016/j.jaad.2004.08.039.Menopause Int. In an article on MSNBC.com, Dr. Judith Reichman indicates that estrogen receptors are located all over the body. We always need to see the results of a number of trials like this. There is clinical data to suggest significant skin thickening and wrinkle reduction from applying Premarin cream or estriol cream. Load up on lots of lush barrier boosting humectants, and bear in mind that that this is also the situ in terms of vaginal dryness. Those taking the A 1996 study published in the International Journal of Dermatology looked at the effects of topical hormone treatment on a group of perimenopausal women. This was despite similar expression of oestrogen receptors, and switching on of the GREB1 gene in response to oestradiol, in the sun-protected and photoaged skin.The researchers conclude that in the postmenopausal women and aged-matched men they studied, “two-week topical estradiol treatment stimulates collagen production in sun-protected hip skin, but not in photoaged forearm or face skin”.They say that this suggests that the decline of oestrogen at the menopause leads to reduced collagen production in sun-protected skin, and that some change in the skin caused by long-term sun exposure reduces the ability of the two-week oestradiol treatment to increase collagen production in aged skin.The researchers were surprised by the results of this study, which will now lead to further studies looking at why oestradiol treatment acts differently in sun-exposed and sun-protected skin.There are a few points to note when interpreting this study:Despite the newspaper headline that oestrogen on the skin can help fight ageing, this study did not investigate the effects of the treatment on the appearance of the skin, but only looked at the presence of procollagens I and III’. Women who are already in menopause or post-menopause can also benefit, but results may not come as quickly or be as dramatic.“The safety study was done [first] to be sure no active estrogen like substances were present in the blood stream, only inactive metabolites,” says study author Zoe Draelos, M.D. Estrogen is a crucial hormone in the body, more so for females. Treatment regimens consisted of a 0.01%, 0.1%, 1% or 2.5% strength of oestradiol administered three times, every other day. It is not a hormone and has none of the potential risks of a hormone, and its mode of action is known.“MEP interacts with the estrogen receptors on the surface of cells such as fibroblasts, stimulating the formation of collagen and elastin and increasing the hydration of the dermis, essentially acting like an estrogen receptor agonist,” explains Dr. Berson.But unlike estrodial, MEP is broken down into an inactive metabolite, which enters the bloodstream and exits the body without being absorbed.“Basically, you are getting the benefit of an estrogen-type product, but with none of the side effects because it is broken down into an inactive ingredient,” says Dr. Berson.According to Elliott Milstein, Senior Vice President of Product Innovation at Ferndale Pharma Group, which manufactures MEP, “Ferndale licensed the basic technology a while ago and spent a lot of time developing the synthesis and scale-up.”It was up to him to figure out how to bring it to market, he says.“It sounds simple, but our market research showed that many women are very uncomfortable talking about estrogen and menopause, even when it is only how it relates to the skin,” says Milstein.The good news is, if a woman begins using MEP before menopause, she can prevent those significant skin changes from happening that begin in early menopause.