During the exercise challenge all dogs received identical care and feeding, and were medicated according to their grouping. In order to maximize bioavailability of omeprazole, all dosing of drugs (both omeprazole and famotidine) was administered at the end of a 7 hour run, and approximately 30 minutes before feeding during the 7‐hour rest period. All research personnel were blinded to group assignment with the exception of the dog owner who administered the treatments. This site needs JavaScript to work properly. eCollection 2017 Jun.Wu JC, Chan FK, Ching JY, Leung WK, Hui Y, Leong R, Chung SC, Sung JJ.Gut. These findings have important clinical implications not only for racing sled dogs, but potentially also for dogs faced with stress‐induced gastric ulceration/erosion from serious disease, trauma, surgery, or both.The 1st experiment was undertaken to determine if the efficacy of famotidine in a 100 mile experimental exercise challenge predicted its efficacy in a 330 mile race. The dogs ran 330 and 300 miles in 66 and 52 hours in the 1st and 2nd studies, respectively. 4). Second, the effect of administration of famotidine was compared with the effect of administering omeprazole instead of placebo. 0 2 4). The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine ( =. 1998 Sep;56(3):447-86. doi: 10.2165/00003495-199856030-00012.Bate CM, Green JR, Axon AT, Murray FE, Tildesley G, Emmas CE, Taylor MD.Aliment Pharmacol Ther. Compare Famotidine vs Nexium head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Of patients leaving the study in symptomatic remission, a greater proportion receiving omeprazole, compared with cimetidine, was free of oesophagitis (84 vs. 53%) (P < 0.05). Dogs receiving famotidine were given ∼1.7 mg/kg (2 × 20 mg tablets) twice daily before meals. During the exercise challenge all dogs received identical care and feeding with the exception that treatment dogs received famotidine in 1 meal each day. Compare Omeprazole vs Pantoprazole head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. 1998 Jan;12(1):49-52. doi: 10.1046/j.1365-2036.1998.00278.x.Richter JE, Peura D, Benjamin SB, Joelsson B, Whipple J.Arch Intern Med. Compared with high‐dose famotidine, omeprazole significantly decreased the severity (0.4 versus 1.2, P= .0002) and prevalence (2/23 versus 7/21, P= .049) of gastric lesions. Both medicines are used to treat heartburn but they work in slightly different ways. While the stress encountered by sled dogs is severe and relatively unique, it may be a reasonable model for submaximal stress from other causes (eg, various forms of shock, severe spontaneous trauma, surgical trauma). Last updated on Oct 3, 2018. Therefore, it is not clear that famotidine will benefit those dogs at greatest risk for severe gastric ulceration/erosion. However, because the gastric severity scores were not significantly better than those in placebo‐treated dogs or omeprazole‐treated dogs, famotidine appears to primarily help animals that are at lesser risk for gastric lesions or are at risk for less severe gastric lesions. Unable to load your collection due to an error Proton Pump Inhibitors and Histamine-2 Receptor Antagonists, Journal of the American Animal Hospital Association, Complications Associated with Nonsteroidal Antiinflammatory Drugs, A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats, Serum concentration of gastrin, cortisol and C-reactive protein in a group of Norwegian sled dogs during training and after endurance racing: a prospective cohort study, Efficacy of Intravenous Administration of Combined Acid Suppressants in Healthy Dogs, The Effect of Orally Administered Ranitidine and Once‐Daily or Twice‐Daily Orally Administered Omeprazole on Intragastric pH in Cats, Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats, Serum Concentrations of Gastrin after Famotidine and Omeprazole Administration to Dogs, Effect of simulated deployment patrols on gastric mucosa of explosive detection dogs, Veterinary Clinics of North America: Small Animal Practice, Clinical pharmacology of nonsteroidal anti‐inflammatory drugs in dogs, Journal of Veterinary Emergency and Critical Care, Efficacy of Oral Famotidine and 2 Omeprazole Formulations for the Control of Intragastric pH in Dogs, Control dogs were fed identical meals except they did not receive famotidine. Approximately, 48 hours after beginning drug administration, the dogs began a 300 mile exercise challenge that was a dedicated experimental exercise, not a competitive sled dog race (January 2009) consisting of pulling a loaded sled over groomed trails.