Ifosfamide (IFO) is an antineoplastic drug that is commonly used to treat gynecological and breast cancers. Like cyclophosphamide, ifosfamide causes a hemorrhagic cystitis in a high proportion of patients, with an occasionally fatal outcome. Although ifosfamide has been administered to a small number of patients with compromised hepatic and/or renal function, studies to establish optimal dose schedules of ifosfamide in such patients have not been conducted. 2014 Jan-Feb;46(1):105-8. doi: 10.4103/0253-7613.125188.Ozguven AA, Yılmaz O, Taneli F, Ulman C, Vatansever S, Onag A.Indian J Pharmacol. 2017 Feb;100:16-19. doi: 10.1016/j.urology.2016.07.030. 2007;23:303-12 6. Sanofi Bangladesh Ltd. CYP3A4 inducers (e.g. Copyright © 2018 Elsevier B.V. All rights reserved. The presence of bacteria or pus in the urine usually indicates infection, although asymptomatic bacteria in the urine is a common finding in older adults (e.g. amobarbital, pentobarbital, phenobarbital, rifampin and secobarbital) may reduce serum levels of ifosfamide while the inhibitors (e.g. Ifosfamide enhances the anticoagulant effect of warfarin. Beacon Pharmaceuticals Ltd. Patients should be monitored accordingly. 2 gm/vial Cell Biol Toxicol. Here, we investigated the role of neutrophils in this inflammatory process. Ifosfamide should be administered as a slow intravenous infusion lasting a minimum of 30 minutes. 2 gm/vial or fucoidan + G-CSF + IFO. The disease can occur as a complication of cyclophosphamide, ifosfamide and radiation therapy. ৳ 3,485.95 This site needs JavaScript to work properly. Therefore, neutrophils contribute to the pathogenesis of HC. In some cases, blood in the urine results from athletic training, particularly in runners. In the unprocessed form, it is much gentler on mucous … Confusion, alopoecia, nausea, vomiting, phloebitis, somnolence, depression, hallucinations. ৳ 1,850.00 Use with mesna and ensure high oral/IV fluid intake to reduce urotoxic effects.Renal Impairment: CrCl <10: Administer 75% of dose.Add 20 ml of sterile water for inj or sterile bacteriostatic water for inj containing benzyl alcohol or parabens for each 1 g of the drug to produce solutions of 50 mg/ml. Ifosfamide (IFO) is an antineoplastic drug that is commonly used to treat gynecological and breast cancers. Wound healing may be impaired during ifosfamide use.Only logged in customers who have purchased this product may leave a review.বাংলাদেশের যেকোনো প্রান্ত থেকে ঘরে বা অফিসে বসে অনলাইনে ও হটলাইন নম্বরে (০১৯৯৯ ৯৯৭৬০৩) ২৪ ঘণ্টার ঔষধের অর্ডার দিতে পারেন। প্রেসক্রিপশন এর ছবি তুলে অথবা স্কান করে আমাদের ওয়েবসাইট অথবা ফেসবুক পেইজের পাঠিয়ে দিন। তাই আমরাই সবচেয়ে সুলভে ভালো ওষুধ সরবরাহ করি।আপনার ইমেইল আমাদের স্বাস্থ্য টিপস, খবর এবং আপডেটের জন্য সাবস্ক্রাইব করুন । আপনার ইমেল ঠিকানা নিচে লিখুন এবং সাবস্ক্রাইব বোতামে ক্লিক করুন।Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our Ifosfamide is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. The damage to urinary bladder epithelium is caused by acrolein, a metabolite that is excreted in the urine. ৳ 2,180.85 These active metabolites act as alkylating agents, disrupting DNA and protein synthesis of the target cells. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Both alkylating agents induce HC, but the incidence of this side effect is higher with IFS treatment (4). ৳ 3,255.00 CYP3A4 inducers (e.g. The risk of hemorrhagic cystitis is dose‑dependent and increased with administration of single high doses compared to fractionated administration. Past or concomitant radiation of the bladder or busulfan treatment may increase the … azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid) may increase its serum levels.Hypersensitivity; severe bone-marrow depression. 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