Any doctor or surgeon who treats you should know that you have an Implanon implant.The Implanon implant must be removed by the end of the third year after it was inserted and may be replaced at that time with a new implant. If you would like more information, talk with your healthcare provider. Adverse reactions were not observed in breastfed infants exposed to etonogestrel through breast milk. The exact location of the implant in the arm should be verified by palpation. After the implant is inserted, your arm will be covered with 2 bandages. Migration of the implants has rarely occurred to the chest wall, as well as within the vasculature including the pulmonary artery. Complete the USER CARD and give it to the woman to keep. Some cases of implants found within the pulmonary artery reported chest pain and/or dyspnea; others have been reported as asymptomatic Consult the labeling of concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of HCs and potentially diminish the effectiveness of HCs or increase breakthrough bleeding.Some drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort. Version: 3.06.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In cases where the implant has migrated to the pulmonary artery, endovascular procedures may be needed for removal.If at any time the implant cannot be palpated, it should be localized and removal is recommended.Exploratory surgery without knowledge of the exact location of the implant is strongly discouraged. Tell your doctor if your periods are very heavy or long-lasting, or if you miss a period (you may be pregnant).If you need surgery or medical tests or if you will be on bed rest, you may need to have your Implanon implant removed for a short time. Pain was the most frequent implant site complication, reported during and/or after insertion, occurring in 2.9% of subjects. If the implant is placed correctly, you will not need to use back-up birth control. Use of this product before menarche is not indicated.This product has not been studied in women over 65 years of age and is not indicated in this population.No studies were conducted to evaluate the effect of hepatic disease on the disposition of Implanon. Any doctor or surgeon who treats you should know that you have an Implanon implant.Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using Implanon.The Implanon implant must be removed by the end of the third year after it was inserted and may be replaced at that time with a new implant. The mean serum etonogestrel concentration decreases gradually over time declining to 192 to 261 pg/mL at 12 months (n=41), 154 to 194 pg/mL at 24 months (n=35), and 156 to 177 pg/mL at 36 months (n=17).The pharmacokinetic profile of Implanon from 1 of 3 pharmacokinetic studies is shown in The apparent volume of distribution averages about 201 L. Etonogestrel is approximately 32% bound to sex hormone binding globulin (SHBG) and 66% bound to albumin in blood.The elimination half-life of etonogestrel is approximately 25 hours. You may report side effects to FDA at 1-800-FDA-1088.Tell your doctor about all medicines you use, and those you start or stop using during your while your Implanon is in place, especially:a barbiturate - butabarbital, secobarbital, phenobarbital (Solfoton); orseizure medicine - carbamazepine, felbamate, oxcarbazepine, phenytoin.This list is not complete. There have been reports of migration of the implant; usually this involves minor movement relative to the original position A non-palpable implant should always be located prior to attempting removal.