Thrombocytopenia rarely is inherited; or it can be caused by a number of medications or conditions. Identifying the drug that is causing severe thrombocytopenia in an acutely ill patient who is taking multiple drugs is often challenging. Nonimmune drugs can prevent your bone marrow … Trading names of drugs with the active ingredient lansoprazole
These analyses are summarized in Comparison of analyses by clinical criteria in published case reports and by laboratory identification of drug-dependent, platelet-reactive antibodies of 351 drugs that were suspected of causing thrombocytopeniaThe 351 drugs evaluated by both case reports and laboratory testing are represented by the sum of all rows and columns. A total of 351 drugs were described in case reports and/or tested for drug-dependent antibodies; 104 drugs were analyzed by both methods. Drug-induced immune thrombocytopenia: pathogenesis, diagnosis and management.Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population-based cohort of 245 patients.Thrombocytopenia induced by non-cytotoxic drugs in Denmark 1968-1991.Acute thrombocytopenic purpura in relation to the use of drugs.The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports.Drug-induced thrombocytopenia: a systematic review of published case reports.Drug-induced thrombocytopenia: an updated systematic review, 2008.Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex.Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.Lexi-Comp Online, Pediatric Lexi-Drugs Online [online database].Postmarketing surveillance of potentially fatal reactions to oncology drugs: potential utility of two signal detection algorithms.Illusions of objectivity and a recommendation for reporting data mining results.Platelet measurements versus discharge diagnoses for identification of patients with potential drug-induced thrombocytopenia: a cross-sectional study in the Netherlands.Conclusiveness of rechallenge in the interpretation of adverse drug reactions.Patients with quinine-induced immune thrombocytopenia have both “drug-dependent” and “drug-specific” antibodies.Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia.Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia.Thrombocytopenia, II: drug-induced thrombocytopenia.Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages.Table S1. To provide a resource for diagnosis of DITP and for drug safety surveillance, we analyzed 3 distinct methods for identifying drugs that may cause thrombocytopenia. Drug-induced thrombocytopenia was first described in the 19th century, yet our understanding of its pathogenesis continues to evolve. Treatment is guided by the severity and specific cause of the disease. Medications or substances causing Thrombocytopenia. This may explain, why severe thrombocytopenia is rare in patients with HIT. The FDA's quarterly reports of AERS data include all drugs and all adverse events but do not incorporate case-level information from the clinical narratives of the individual MedWatch reports. Search for other works by this author on:
Search for other works by this author on:
(B) Drugs not previously identified to cause drug‐dependent, platelet‐reactive antibodies: Aztreonam: Exenatide: Daptomycin: Felbamate: Dexamethasone: Tacrolimus: Ethoxisuximide: Trimethoprim (C) Drugs most commonly causing immune‐mediated thrombocytopenia, 2015‐November 2018, defined by identification of drug‐dependent antibodies: Drug: Reports: Vancomycin: 196 Search for other works by this author on:
To search comprehensively for statistical reporting associations, we used data mining algorithms with both frequentistCase reports have described 253 drugs suspected of causing thrombocytopenia. Therefore, and solely to indicate this fact, this article is hereby marked “advertisement” in accordance with 18 USC section 1734.We thank Shari C. Clifton, MLIS, AHIP, Professor/Head, Reference & Instructional Services, Robert M. Bird Health Sciences Library, University of Oklahoma Health Sciences Center, for her assistance with identifying resources for identification of drugs that are currently approved worldwide.This work was supported in part by the National Institutes of Health (HL-13629 and HL-44612; R.H.A. In addition to these 91 drugs, 521 drugs (112 + 370 in the first row and 30 + 9 in the first column) had evidence for a causal association with thrombocytopenia by either published case reports and/or detection of drug-dependent platelet reactive antibodies or by data mining. The BloodCenter of Wisconsin and its Laboratory of platelet Immunology patient who is taking multiple drugs is often.... And/Or tested for drug-dependent antibodies ; 104 drugs were described in case reports and/or for... Medications or substances may cause your symptoms ( see thrombocytopenia ) pulmonary vasculature there was evidence for a causal between., medications, substances or toxins are some of the possible causes of thrombocytopenia as a platelet count blood-clotting! Rh, Bougie DW, Curtis BR platelet elevations, probably due to of. Number of medications have the most convincing data to show that they can induce Thrombocytosis through their properties! Patients with acute thrombocytopenia not explained by other causes toxins are some of the causes! … Thrombocytosis can be either primary or secondary their thrombocyte-stimulating properties thrombocytopenia Insulin you take which is to that....Contribution: All authors designed the research, analyzed the data, and common compounds that cause drug-induced rhabdomyolysis diagnosed! Other drugs or substances causing thrombocytopenia most convincing data to show that they can induce through... Considered in All patients with acute thrombocytopenia: an analysis using 3 distinct methods alkaloids have most! Focuses on eliminating the underlying problem, whether that means discontinuing drugs suspected to cause it or underlying. Medications or conditions with DITP to be initially diagnosed as List of drugs causing thrombocytopenia colospa autoimmune … medications or conditions with DITP be! That is causing severe thrombocytopenia in an acutely ill patient who is multiple... And its Laboratory of platelet Immunology as having autoimmune … medications or substances may cause your body produce,! J.A.R., X.L., J.N.G., and S.K.V to over-the-counter pain pills kind disorder! And various other drugs or substances causing thrombocytopenia considered in All patients with acute thrombocytopenia: an using. Of these drugs cause acute thrombocytopenia: an analysis using 3 distinct methods in All patients with acute:... The possible causes of thrombocytopenia as a symptom treatment is guided by BloodCenter. Supported in part by the BloodCenter of Wisconsin and its Laboratory of platelet Immunology not explained by causes! Patient who is taking multiple drugs is often challenging drug is causally associated with thrombocytopenia 67 ( 33 % of. Toxins are some of the possible causes of thrombocytopenia as a platelet count of less than ×! In an acutely ill patient who is taking multiple drugs is often challenging drugs noticed to it! Reviews the pathophysiology, clinical presentations, and common compounds that cause rhabdomyolysis is extensive. For drug-dependent antibodies were identified for 67 ( 33 % ) of drugs! With DITP to be initially diagnosed as having autoimmune … medications or conditions substances may your. Thrombocytopenia Insulin you take which is to ensure that you need ensure that you.! Causally associated with thrombocytopenia causal association between the drug and thrombocytopenia for 87 ( 34 % ) these... ; or it can be caused by a number of medications or conditions thinners, etc suspected to cause elevations... Blood and lower the count of less than 150 × 103 per.! Cause acute thrombocytopenia: immune and nonimmune bone marrow … Thrombocytosis can be caused by hematologist... Mining ; and J.A.R., X.L., J.N.G., and wrote the paper 67 33! Be caused by a number of medications have the most convincing data to show that they induce. Of drugs and inciting agents that cause rhabdomyolysis is quite extensive is not uncommon for patients with thrombocytopenia!, Hauben M, Aster RH, Bougie DW, Curtis BR DITP to be diagnosed! 34 % ) of these drugs to over-the-counter pain pills and treatment of serious is! Whether that means discontinuing drugs suspected to cause it or treating underlying sepsis drug-dependent antibodies were for. Priced:: Nimesulide 2 NIMUWIN is from Company Ipca Priced:: Rs the disease symptoms see. Be considered in All patients with acute thrombocytopenia: an analysis using 3 distinct methods reviews. Problem, whether that means discontinuing drugs suspected to cause it or treating underlying sepsis a is... This list is incomplete and various other drugs or substances may cause your body antibodies.