Do not take mefenamic acid in larger amounts or for longer than recommended. If you are 65 or older, use mefenamic acid with care. Mefenamic acid is an extremely weak basic (essentially neutral) compound (based on its pKa). Keep the bottle tightly closed when not in use.Read all patient information, medication guides, and instruction sheets provided to you. Skip the missed dose if it is almost time for your next scheduled dose. Diclofenac was the product of rational drug design based on the structures of phenylbutazone, mefenamic acid, and indomethacin. MA is a weak acid (pKa=4.32) and easily ionizes at higher pH . As the situation with COVID-19 continues to unfold in every communities, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. Solubilities of six pharmaceuticals, namely nadolol, atenolol, bifonazole, nimesulide, estrone, mefenamic acid at constant pH, were measured over the range of temperature from (240 to 340) K in three important for drug solvents: water, ethanol, and 1-octanol using the dynamic method and spectroscopic UV–Vis method. An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase. 12 The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. Other drugs may interact with mefenamic acid, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc. Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. advice about side effects. It may increase your risk of stomach bleeding.Avoid taking aspirin while you are taking mefenamic acid.Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with ICRoom temperature in continental US; may vary elsewhere.Solubility: 2.5 mg/mL (10.36 mM); Suspended solution; Need ultrasonicMass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)Please fill out this form to request the QC report. pKa 4.2. uv max (0.lN NaOH): 285, 340 nm. We comply with the HONcode standard for trustworthy health information - Mefenamic Acid is an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic … Call your doctor or get medical Mefenamic acid belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). You may report side effects to the FDA at 1-800-332-1088. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: 7.16.3.7 Other NSAIDs. The basic thermal properties of pure drugs i.e . You could have more side effects. The metabolism of mefenamic acid has received particular attention because of the formation of reactive metabolites (Horng and Benet 2013; Venkataraman et al.