There were dissolution problems. In 2008 the FDA warned Sandoz that its formulation of metoprolol succinate had not been properly validated. Metoprolol is in a class of medications called beta blockers. Close more info about Major Recall of Metoprolol ER Tablets India’s Dr. Reddy's Laboratories has announced it is voluntarily recalling 13,560 bottles of hypertension drug metoprolol succinate in the U.S., due to the high blood pressure drug failing a dissolution test.Metoprolol succinate extended release is a less expensive generic form of AstraZeneca's Toprol XL.This recall comes on the heels of Wockhardt Ltd.'s recall of 109,744 bottles of the same drug last month for the same reason. Administer once daily. Generic manufacturer Dr. Reddy’s is recalling two lots (about 13,560 bottles) of blood pressure med metoprolol ER (metoprolol succinate, or generic Toprol XL).The recall includes only the 25 mg tablet, 100-count bottle.. Selected from data included with permission and copyrighted by First Databank, Inc. The recalled lots were manufactured at a Wockhardt plant in Mumbai, India. Heart Failure: In the MERIT-HF study comparing metoprolol succinate extended-release tablets in daily doses up to 200 mg (mean dose 159 mg once-daily; n=1990) to placebo (n=2001), 10.3% of metoprolol succinate extended-release tablet patients discontinued for adverse reactions vs. 12.2% of placebo patients. Close more info about Major Recall of Metoprolol ER Tablets Metoprolol is the generic form of the brand name drugs Lopressor, Metoprolol Succinate, Metoprolol Tartrate and Toprol XL. These don't reflect the entire product lines, but the specific lots identified in each recall event. Dissolution tests verify the time taken for the active ingredient to release into the body, and help predict how the drug performs inside the body.The affected 50mg tablets are supplied in 30-count bottles and have Lot # LN10686, LN10687, LN10688, LN10707, LN10708 with an expiration date of 02/15. Close more info about Major Recall of Metoprolol ER Tablets A History of Generic Metoprolol Recalls. © 2005-2020 Healthline Media a Red Ventures Company. Metoprolol succinate has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. Dissolution tests are conducted to check the time it takes for the active ingredient in a drug to release into the body, and help predict how the drug performs inside the body. Over the last several years there have been a number of recalls of generic metoprolol. Healthline Media does not provide medical advice, diagnosis, or treatment. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. metoprolol succinate er plus hydrochlorothiazide Calcium Channel Blockers KATERZIA amlodipine HMG & Cholesterol Inhibitor Combinations ALTOPREV, EZALLOR SPRINKLE, SIMVASTATIN SUSPENSION ... LUMIGAN, ZIOPTAN Ophthalmic Anti-Allergic ALOCRIL, ALOMIDE, LASTACAFT, PAZEO azelastine drops, cromolyn drops, epinastine drops, Although not all of these side effects may occur, if they do occur they may need medical attention. Metoprolol succinate, is a beta 1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. Reddy's began to voluntarily recall metoprolol succinate on May 23, 2014; the recall was posted on the FDA website on June 19, 2014.An FDA spokesman told Healthline, "The recent Wockhardt and Dr. Reddy's metoprolol succinate recalls are independent isolated events that the companies are voluntarily addressing. According to the Food and Drug Administration (FDA), the recall of Dr. Reddy's metoprolol succinate extended release tablets, USP 25 mg. 100-count bottle, is a Class II recall. Likewise, there is nothing to be found readily on the FDA's web site about this Sandoz Metoprolol Succinate ER Tablets recall. If you have more information about how Sandoz is carrying out this relatively "quiet" recall of its Metoprolol Succinate ER Tablets, please let us know by submitting a Comment, below, or sending me a private email. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. (Heart Failure: Recommended starting dose is 12.5 mg or 25 mg doubled every two weeks to the highest dose tolerated or up to 200 mg. ()Hypertension: Usual initial dosage is … Wockhardt announced a recall of 109,744 bottles of Metoprolol Succinate Extended-Release 50mg Tablets, the generic version of AstraZeneca’s Toprol XL.. This recall was initiated due to a dissolution test failure observed at the nine month time point. Metoprolol is a beta-blocker used to treat hypertension (high blood pressure), angina (chest pain) and other heart-related conditions. Healthline Media does not provide medical advice, diagnosis, or treatment. "Healthline contacted a Dr. Reddy's spokesperson in India, who said the company has put a corrective action plan in place.© 2005-2020 Healthline Media a Red Ventures Company.