www.consumerlab.com/answers/cbd-interactions-with-other-drugs-medications/cbd-drug-interactions/Join now to save favorites and get all member benefits, including over 1,300 reviews.Learn more about cannabidiol (CBD), its potential effects, safety and side effects, and find out if CBD oils and pill are legal. Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol (e.g., cell membranes), rosuvastatin may cause fetal harm when administered to pregnant women. ConsumerLab.com name and flask logo are both registered trademarks of ConsumerLab.com, LLC. Statins Can Still Benefit Your Heart People have used the seed to make medicine for over 2000 years. Management: Initiate rosuvastatin at 5 mg daily and limit the rosuvastatin dose to a maximum of 10 mg per day during coadministration with elbasvir/grazoprevir. ConsumerLab's answer explains.Find out if CBD (cannabidiol) oil can help reduce symptoms of Parkinson's disease, including motor symptoms such as tremor, and non-motor symptoms such as mood and sleep disturbances. When you take calcium channel blockers and cardiac glycosides together, you risk having increased digoxin levels, which can result in a cardiac glycoside overdose.Carol Luther has more than 25 years of business, technology, and freelance writing experience. Management: Consideration a preventive 50% reduction in rosuvastatin adult dose when starting this combination.Eluxadoline: May increase the serum concentration of Rosuvastatin. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Ezallor Sprinkle: 5 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]Ezallor Sprinkle: 10 mg, 20 mg [contains brilliant blue fcf (fd&c blue #1)]Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis (reduces the production of mevalonic acid from HMG-CoA); this then results in a compensatory increase in the expression of LDL receptors on hepatocyte membranes and a stimulation of LDL catabolism. This side effect of Tulsi can lead to complications during childbirth or menstruation. Colchicine may increase the serum concentration of HMG-CoA Reductase Inhibitors (Statins).CycloSPORINE (Systemic): May increase the serum concentration of Rosuvastatin. Specifically, the risk of skeletal muscle toxicity may be increased. Ginseng is a stimulant that can increase your blood pressure. Select one or more newsletters to continue. Concentrations and effects of the BCRP/ABCG2 substrate would be expected to increase with combined use.Trabectedin: HMG-CoA Reductase Inhibitors (Statins) may enhance the myopathic (rhabdomyolysis) effect of Trabectedin. This will allow your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride levels and to decide if you should continue to take it. There are reports of congenital anomalies following maternal use of HMG-CoA reductase inhibitors in pregnancy; however, maternal disease, differences in specific agents used, and the low rates of exposure limit the interpretation of the available data (Godfrey 2012; Lecarpentier 2012). One of the holy basil side effects also include increase in uterine contractions in pregnant women . Management: Rosuvastatin dose should not exceed 10 mg/day with concurrent use of atazanavir and cobicistat or 20 mg/day with concurrent use of darunavir and cobicistat.Colchicine: May enhance the myopathic (rhabdomyolysis) effect of HMG-CoA Reductase Inhibitors (Statins). Concentrations and effects of the OATP1B1/1B3 substrate would be expected to increase with combined use.Tolvaptan: May increase the serum concentration of BCRP/ABCG2 Substrates. You may need a lower than normal starting dose.Follow all directions on your prescription label and read all medication guides or instruction sheets. A common adverse effect of combining pleurisy root and a calcium channel blocker is decreased kidney clearance of digoxin, the active cardiac glycoside in plants in the foxglove family. The Hindu name for holy basil, Tulsi, means "the incomparable one." Symptoms? Management: Limit rosuvastatin to 5 mg daily in patients who are also receiving cyclosporine, and monitor patients for increased rosuvastatin toxicities. How? Management: Limit the rosuvastatin dose to a maximum of 10 mg per day when used with the ombitasvir/paritaprevir/ritonavir/dasabuvir combination product. Management: Limit the dose of rosuvastatin to 10 mg daily when combined with regorafenib. Consider dosage reduction if unexplained hematuria and proteinuria persists.• Hepatotoxicity: Postmarketing reports of fatal and nonfatal hepatic failure are rare.