This information is intended for use by health professionalsEach film-coated tablet contains sertraline hydrochloride equivalent to 50 mg sertraline. Patients randomized to sertraline showed significantly greater improvement than those randomised to placebo on the Children's Yale-Brown Obsessive Compulsive Scale CY-BOCS (p =0.005) the NIMH Global Obsessive Compulsive Scale (p=0.019), and the CGI Improvement (p =0.002) scales. Also patients taking diuretics or who are otherwise volume-depleted may be at greater risk (see Use in elderly). Concomitant intake of pimozide is contraindicated (see section 4.5). After the satisfactory response, continuation with sertraline therapy is effective … methylene blue), antipsychotics and other dopamine antagonists, and with opiate drugs. While the mechanism of this interaction is unknown, due to the narrow therapeutic index of pimozide, concomitant administration of sertraline and pimozide is contraindicated (see section 4.3). Ask your doctor how to safely stop using sertraline.Store at room temperature away from moisture and heat.Take the missed dose as soon as you remember. The half-life of N-desmethylsertraline is in the range of 62 to 104 hours. SSRIs or SNRIs including sertraline have however been associated with cases of clinically significant hyponatraemia in elderly patients, who may be at greater risk for this adverse event (see Hyponatraemia in section 4.4). There were no significant differences between boys and girls regarding clearance. Sertraline is extensively metabolised, and excretion of unchanged drug in urine is a minor route of elimination. Sertraline should be discontinued in any patient entering a manic phase.Psychotic symptoms might become aggravated in schizophrenic patients.Seizures may occur with sertraline therapy: sertraline should be avoided in patients with unstable epilepsy and patients with controlled epilepsy should be carefully monitored. Stay alert to changes in your mood or symptoms. The following adverse reactions were reported from controlled trials (n=281 patients treated with sertraline):Epidemiological studies, mainly conducted in patients 50 years of age and older, show an increased risk of bone fractures in patients receiving SSRIs and TCAs. This dosage regimen has been shown to reduce the frequency of early treatment emergent side effects characteristic of panic disorder.Patients not responding to a 50 mg dose may benefit from dose increases. Hyponatraemia may occur as a result of treatment with SSRIs or SNRIs including sertraline. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), agitation or anxiety, nausea and/or vomiting, tremor and headache are the most commonly reported reactions. Chronic dosing with sertraline 50 mg daily showed moderate elevation (mean 23%-37%) of steady-state desipramine plasma levels (a marker of CYP 2D6 isozyme activity). I didn't expect it to be as acute as this though. Physicians must monitor paediatric patients on long term treatment for abnormalities in growth and development.There have been reports of bleeding abnormalities with SSRIs including cutaneous bleeding (ecchymoses and purpura) and other haemorrhagic events such as gastrointestinal or gynaecological bleeding, including fatal haemorrhages. The mean dose for completers was 70 mg/day. I'm on 1500 calories a day and am active and in the gym 2-3 times per week. Do not take extra medicine to make up the missed dose.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. In addition, these conditions may be co-morbid with major depressive disorder. Hi, apologies if this has been covered before, but I've been on 50mg for over a year since the birth of my second DC. anticoagulants, atypical antipsychotics and phenothiazines, most tricyclic antidepressants, acetylsalicylic acid and non-steroidal anti-inflammatory drugs (NSAIDs)) as well as in patients with a history of bleeding disorders (see section 4.5).Hyponatraemia may occur as a result of treatment with SSRIs or SNRIs including sertraline. Severe adverse reactions have been reported in patients who have recently been discontinued from an MAOI (e.g. methylene blue) and started on sertraline, or have recently had sertraline therapy discontinued prior to initiation of an MAOI. Safe, effective and popular, sertraline is a widely used antidepressant that’s part of the selective serotonin reuptake inhibitor (SSRI) class of medications. To date, no adverse effects on the health of infants nursed by mothers using sertraline have been reported, but a risk cannot be excluded. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish sertraline from benzodiazepines.SSRIs including sertraline may have an effect on pupil size resulting in mydriasis. It cannot be excluded that other CYP3A4 inducers, e.g.