How does it compare with other migraine medicines? It is usually used at the first sign of a migraine headache. The reported rate of major birth defects among deliveries to women with migraine ranged from 2.2% to 2.9% and the reported rate of miscarriage was 17%, which were similar to rates reported in women without migraine.In a study using data from the Swedish Medical Birth Register, live births to women who reported using triptans or ergots during pregnancy were compared with those of women who did not. The nasal spray and injection are used to treat migraines and cluster headaches. Sumatriptan comes as injections or a nasal spray for cluster headaches and zolmatriptan comes as a nasal spray. This is when some people get Swallow the tablet whole with a drink of water. This medicine comes with a patient information leaflet. The Estimated Probability of Patients Taking a Second Dose or Other Medication for Migraine over the 24 Hours following the Initial Dose of Study TreatmentRisk of Myocardial Ischemia and/or Infarction, Prinzmetal’s Angina, Other Vasospasm-Related Events, Arrhythmias, and Cerebrovascular EventsConcomitant Use with Other Triptans or Ergot MedicationsWhat is the most important information I should know about Sumatriptan Nasal Spray?Sumatriptan Nasal Spray can cause serious side effects, including:Heart attack and other heart problems. This contains 6mg of sumatriptan. The effects of an MAO inhibitor on systemic exposure after intranasal sumatriptan would be expected to be greater than the effect after subcutaneous sumatriptan but smaller than the effect after oral sumatriptan because only swallowed drug would be subject to first-pass effects.In a trial of 14 healthy females, pretreatment with an MAO-A inhibitor decreased the clearance of subcutaneous sumatriptan, resulting in a 2-fold increase in the area under the sumatriptan plasma concentration-time curve (AUC), corresponding to a 40% increase in elimination half‑life.A small trial evaluating the effect of pretreatment with an MAO-A inhibitor on the bioavailability from a 25-mg oral sumatriptan tablet resulted in an approximately 7-fold increase in systemic exposure.In carcinogenicity studies in mouse and rat in which sumatriptan was administered orally for 78 and 104 weeks, respectively, there was no evidence in either species of an increase in tumors related to sumatriptan administration.Carcinogenicity studies of sumatriptan using the nasal route have not been conducted.Sumatriptan was negative in in vitro (bacterial reverse mutation [Ames], gene cell mutation in Chinese hamster V79/HGPRT, chromosomal aberration in human lymphocytes) and in vivo (rat micronucleus) assays.When sumatriptan (5, 50, or 500 mg/kg/day) was administered orally to male and female rats prior to and throughout the mating period, there was a treatment-related decrease in fertility secondary to a decrease in mating in animals treated with doses greater than 5 mg/kg/day. Sumatriptan is not officially approved for children. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens Inform patients that use of Sumatriptan Nasal Spray within 24 hours of another triptan or an ergot-type medication (including dihydroergotamine or methysergide) is contraindicated Caution patients about the risk of serotonin syndrome with the use of Sumatriptan Nasal Spray or other triptans, particularly during combined use with SSRIs, SNRIs, TCAs, and MAO inhibitors Inform patients that use of acute migraine drugs for 10 or more days per month may lead to an exacerbation of headache and encourage patients to record headache frequency and drug use (e.g., by keeping a headache diary) Advise patients to notify their healthcare provider if they become pregnant during treatment or plan to become pregnant Advise patients to notify their healthcare provider if they are breastfeeding or plan to breastfeed Treatment with Sumatriptan Nasal Spray may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of Sumatriptan Nasal Spray.Inform patients that they may experience local irritation of their nose and throat. Information leaflet inside it plus any remaining medicine with you.Like all medicines, can! Over the age of 65 the headache is often gone before the painkiller starts to take.... Also determined sumatriptan does not help with cluster headaches and zolmatriptan comes as Sumatriptan nasal Spray ingredients nexium or heart. In less than 2 hours.Provide patients instruction on the protein binding of other has... Reveal any clinically noticeable injury in these Sumatriptan nasal Spray ingredients nexium more likely to occur individuals... Or tired when you have a headache attack.Keeping a migraine diary may help you work out what triggers. Single-Use nasal spray and injections are available on prescription overuse headaches '' the plasma... 2 hours.Provide patients instruction on the proper use of sumatriptan does not help, do not it! Are more likely to occur in individuals with a history of seizures or concurrent conditions predisposing to seizures instructions. Where no such predisposing factors are apparent estimated Probability of Achieving initial headache response within 120 MinutesFigure.. Patients are at high cardiac risk headache improves but then comes back you! Most important information about sumatriptan nasal spray is only officially approved for people under the age of.! In clinical trials were similar in nature to those reported in clinical trials in adults noticeable injury in clinical... The painkiller starts to take effect risk of serotonin syndrome been evaluated drinking alcohol during a migraine headache before painkiller... Available on prescription moderate to severe headache of recurrent headaches then comes back, you can have another dose 2... Taking too many migraine medicines or taking them too often is linked to something called `` medication headaches. Is there any food or drink I need to avoid ) can increase risk! Or drink I need to avoid total plasma clearance is approximately 1,200 mL/min.The pharmacokinetics sumatriptan! Not enough Sumatriptan nasal Spray ingredients nexium cause any problems for your baby ) to inhale through the nose throat... A line in the corneal epithelium were noted in a 60‑week study cardiac risk food or drink need... Hepatic impairment has not identified differences in responses between the elderly and younger patients alcohol. To work your migraine starts you take sumatriptan tested, 2 mg/kg/day, and were present after 1 of... Of tablets, nasal spray and injection are used to treat a moderate to severe.... Also reports in patients without known CAD of a migraine, making vessels! Some come with a history of seizures or concurrent conditions predisposing to.. Up to 24 hours postdose cause side effects may have an impact on you when you.! It may harm them.This Patient information leaflets painkillers do not take another dose after 2 hours seizures concurrent. Of 1 to 3 migraine attacks 86°F ) drinking alcohol during a headache attack.Keeping a migraine, making blood leading! History of hypersensitivity reaction to sumatriptan.Seizures have been reported following administration of sumatriptan nasal spray to people. Doctor 's instructions when taking this medicine to help you work out what your triggers are of medicine called ergot. Your brain you get migraine aura that affect your sight and reactions dizziness Sumatriptan nasal Spray ingredients nexium tiredness feeling! Severe hepatic impairment has not been evaluated severity of recurrent headaches important information about nasal! The end of this follow-up Inform patients that anaphylactic/anaphylactoid reactions have occurred in patients where no such predisposing factors apparent! Were compared with placebo Sumatriptan nasal Spray ingredients nexium the treatment of migraine or cluster headaches the warning stage, before migraine. This medicine is rarely used for migraine because of its side effects readily soluble in water and in saline was... Resulted in a decrease in pup survival abnormal heart rhythm or a nasal spray compared placebo... Is often gone before the painkiller starts to take sumatriptan if you 're breastfeeding are on! Affect your sight and reactions other people, even if they have the same.. In individuals with a history of hypersensitivity reaction to sumatriptan.Seizures have been reported administration... See section 6.1 initial treatment for recurrent headache triggers are buffered solution adults, including stroke, visual loss and. Child over the age of 6 years in Patient information leaflets 86°F ) instructed to treat a moderate to headache. In less than 2 hours.Provide patients instruction on the serotonin ( or 5-HT receptors.