The following process is based on an assumed regimen of two prescription-strength PPIs per day. "But an expert not involved in the study said it's unclear whether PPIs, themselves, are responsible for the higher death rates.Dr. He said the current study, like others before it, is "observational" -- that is, it used medical records to track patients' outcomes.Those types of studies cannot prove cause and effect, Kim said. You may likely experience rebound, and will need to tough that out. Key points to remember: Don’t go too fast. They include prescription and over-the-counter drugs like Research in recent years has linked prolonged PPI use to increased risks of various diseases and premature death.These latest findings point to the specific causes of death tied to the drugs, said lead researcher Dr. Ziyad Al-Aly.He stressed that the excess risks were relatively small. H2 receptor blockers can interfere with the effectiveness of PPIs. It's the latest to raise concerns over drugs called proton pump inhibitors (PPIs). H2 for 1, week 2 would be 5 days PPI, week 3 4 days etc. First we learned that people taking a PPI are more susceptible to pneumonia (JAMA, May 27, 2009). I am impressed by your doctor's efforts to help you switch from a PPI to an H2 blocker. The process can be adjusted, as necessary, if you have a different starting point. We do this by providing high quality disease, treatment, and weight loss information on our website and in our books, and we connect those suffering from this chronic condition with GERD experts for diagnosis and treatment.Please note, RefluxMD does not provide medical advice. I was on PPI for 15 years. I had a schedule whereby week one I would do PPI for 6 days. Norm Robillard. "It suggests a lot of people were using a PPI without actually needing one," he said. That includes people with recurrent stomach ulcers or Before you start a PPI, Al-Aly said, be sure you actually need one. And millions more buy them over the counter without a doctor's knowledge.The findings were published recently in the journal Over the next 10 years, 38% of PPI users died, as did nearly 36% of those on H2 blockers.If PPIs contribute to deaths, it's unclear why. Over the next 10 years, 38% of PPI users died, as did nearly 36% of those on H2 blockers… That allows damaged tissue in the "Most people don't need to be on a PPI for months or years," Al-Aly said.In this study, the risks linked to PPIs rose with prolonged use. PPIs down to H2 blockers down to antacids, Wean off a high dose down to low dose, Frequent use to less frequent use. "They could be taking a risk without deriving any benefit. According to Al-Aly, lab research has hinted the drugs may cause dysfunction in the lining of the blood vessels, or disrupt the gut's immune function and normal bacterial makeup.WebMD does not provide medical advice, diagnosis or treatment.SOURCES: Ziyad Al-Aly, M.D., assistant professor, medicine, Washington University School of Medicine in St. Louis; Lawrence S. Kim, M.D., member, governing board, American Gastroenterological Association, Bethesda, Md. If you read through these posts, you will find much good advise from others. Law and tracks, whatever direction you go, your first step is to step down from PPI to H2 blocker. Maybe that's all you intend to do, it would be an improvement for you I believe. It … The basic goals are to gradually move from:RefluxMD’s vision is to help adults with acid reflux disease to live healthier and happier lives. THURSDAY, June 6, 2019 (HealthDay News) -- People who use common The study included more than 200,000 U.S. veterans. After all the info started coming out, I decided to switch to H2 blockers. There may be other explanations for the higher risks seen among PPI users.In 2017, Kim said, the gastroenterological association published a review of the research into the issue. "However we looked at the data, there was a consistent [link] with PPI use and risk of death," Al-Aly says. For example, over 10 years, 13% of PPI users died of a cardiovascular condition, including heart disease or When the researchers weighed other factors -- such as patients' age and chronic health conditions -- PPI use was tied to a roughly 18% higher risk of cardiovascular death.However, based on patients' medical records, many of those with PPI prescriptions had no documented need for one. PPI users with those who took neither PPIs nor H2 blockers. See our Relieve heartburn symptoms by drinking alkaline water The drugs are available over the counter, but they should not be used for more than a couple weeks without talking to a doctor, he said.If you've used a PPI for a long time, Kim said, talk to your doctor about whether you need to continue.According to the study, more than 15 million Americans have PPI prescriptions. "The report concluded that the evidence supporting all of these risks was low- to very-low quality," he said. After about a week, I said screw it & went full H2. "That's unsettling," said Al-Aly, an assistant professor at Washington University School of Medicine in St. Gradually, however, data have accumulated showing that the PPI drugs are not really as safe as they appeared. 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