Some other examples of serious blood clots include blood clots in the legs or eyes.Call your healthcare provider or go to a hospital emergency room right away if you have:changes in the sugar and fat (cholesterol and triglycerides) levels in your bloodnew or worsening headaches including migraine headachesirregular or unusual vaginal bleeding and spotting between your menstrual periods, especially during the first 3 months of taking Tri-Lo-Sprintec.swelling of your skin especially around your mouth, eyes, and in your throat (angioedema).dark patches of skin around your forehead, nose, cheeks and around your mouth, especially during pregnancy (chloasma).What are the most common side effects of Tri-Lo-Sprintec?What else should I know about taking Tri-Lo-Sprintec?General information about the safe and effective use of Tri-Lo-Sprintec.What should I know about my period when taking Tri-Lo-Sprintec?What should I do if I miss any Tri-Lo-Sprintec pills?If you start taking Tri-Lo-Sprintec and you have not used a hormonal birth control method before:If you start taking Tri-Lo-Sprintec and you are switching from another birth control pill:If you start taking Tri-Lo-Sprintec and previously used a vaginal ring or transdermal patch:If you start taking Tri-Lo-Sprintec and you are switching from a progestin-only method such as an implant or injection:If you start taking Tri-Lo-Sprintec and you are switching from an intrauterine device or system (IUD or IUS):Tri-Lo-Sprintec comes in a blister pack tablet dispenser.Three Ways to Remember in What Order to Take the PillsWhat should I do if I miss any Tri-Lo-Sprintec pills?If you miss 1 pill in Weeks 1, 2, or 3, follow these steps:If you miss 2 pills in Week 1 or Week 2 of your pack, follow these steps:If you miss 2 pills in a row in Week 3, or you miss 3 or more pills in a row during Weeks 1, 2, or 3 of the pack, follow these steps:If you have any questions or are unsure about the information in this leaflet, call your healthcare provider.norgestimate and ethinyl estradiol tablet, film coatednorgestimate and ethinyl estradiol tablet, film coatednorgestimate and ethinyl estradiol tablet, film coatedWe comply with the HONcode standard for trustworthy health information - ; If you miss 2 periods in a row, take a pregnancy test before starting a new cycle.WHAT DO I DO IF I MISS A DOSE? If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects. ; Period (menstrual) changes. Interactions between COCs and other drugs may lead to breakthrough bleeding and/or contraceptive failure. Medication prices vary by pharmacy location or chain and are subject to change. A small proportion of women will have adverse lipid changes while on COCs.Women with hypertriglyceridemia, or a family history thereof, may be at an increased risk of pancreatitis when using COCs.If a woman taking Tri-Lo-Sprintec develops new headaches that are recurrent, persistent, or severe, evaluate the cause and discontinue Tri-Lo-Sprintec if indicated.Consider discontinuation of Tri-Lo-Sprintec in the case of increased frequency or severity of migraine during COC use (which may be prodromal of a cerebrovascular event).Unscheduled (breakthrough or intracyclic) bleeding and spotting sometimes occur in patients on COCs, especially during the first three months of use. I took it for 3 years without a scare. CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.Significant changes (increase or decrease) in the plasma concentrations of estrogen and/or progestin have been noted in some cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir])/HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine] or increase [e.g., etravirine]).The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.Do not co-administer Tri-Lo-Sprintec with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT elevations There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy. Irregular vaginal bleeding or spotting may happen while you are taking Tri-Lo-Sprintec, especially during the first few months of use. You may need to use back-up If you often forget to take your pills as directed, contact your doctor to discuss switching to another form of birth control.Store at room temperature away from light and moisture. ; This drug may cause dark patches of skin on your face.