Altered PT and/or INR, infrequently associated with hemorrhagic or thrombotic
Wellbutrin is a pregnancy category C drug, meaning that it has been shown to have adverse effects on the fetus in animal studies and that not enough studies have been conducted to determine the effect it may have in humans. The reported adverse events included vomiting, diarrhea, jitteriness, sleepiness, hypotony and a seizure (reported in the SSRI group). Important information. adverse reactions are defined as those occurring in at least 1/100 subjects. Get medical help right away if you experience any of the following while taking any version of Wellbutrin: [1]Ten women who were an average of 12.5 months postpartum and who did not nurse their infants after the start of bupropion therapy took sustained-release bupropion 150 mg daily for 3 days, then 300 mg daily for 4 days. The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. 35% of subjects receiving tricyclic antidepressants gained weight, only 9.4% of
Ann Pharmacother. However, there is little reported use in breastfed newborn infants and case reports of a possible seizure in partially breastfed 6-month-olds. 2010;5:283-8. Bupropion and breastfeeding: a case of a possible infant seizure. [13] The antidepressants used by the mothers were not specified.A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). The mother had been taking escitalopram 10 mg daily since birth and had begun extended-release bupropion 150 mg daily 3 weeks earlier. Some side effects of Wellbutrin can be severe or even potentially life-threatening. 2017;33:701-9. J Perinatol. To help you remember, take it at the same times each day. On the seventh day, breastmilk levels of the drug and metabolites were measured at a median 2.5 hours (range 1 to 12 hours) after the last dose. The infant's serum at this time contained a detectable, but non-quantifiable level of bupropion (<4.8 mcg/L) and a serum hydroxybupropion level of 11.2 mcg/L. Infrequent adverse reactions are those occurring in 1/100 to 1/1,000 subjects,
2004;13:52-6. Additionally, another brand of bupropion (the active ingredient in Wellbutrin) called Zyban is used to help people [3]Four women were taking bupropion SR 150 mg or 300 mg for depression or smoking cessation. Also, stopping abruptly can lead to discontinuation syndromeEverything feels more challenging when you're dealing with depression. Hepatic impairment. Breast feeding. J Clin Psychiatry. No specific details were given on the 2 women who breastfed their infants, but neither noted any adverse effects in their infants. WELLBUTRIN SR may be taken with or without food. There are a number of potential interactions that can occur when other substances are taken at the same time as Wellbutrin. [PubMedBaab SW, Peindl KS, Piontek VM et al. The seizure was probably drug-related, most likely caused by bupropion and hydroxybupropion in breastmilk, but a contribution by escitalopram cannot be ruled out. therefore seizures are probably not a major concern in these infants. Immediate release Wellbutrin tablets can be broken if necessary, but they are small enough that that is not usually needed. serum sickness [seeHypertension (in some cases severe), orthostatic
In either case, don't stop taking Wellbutrin until you've checked with your doctor first. Get our free guide when you sign up for our newsletter.Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C. Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-coughlin S. College of Psychiatric and Neurologic Pharmacists.