Clinical and economic impact of a pharmacist-intervention to promote sequential intravenous to oral clindamycin conversion. Cost-effectiveness of abbreviating the duration of intravenous antibacterial therapy with oral fluoroquinolones. Empiric oral monotherapy for hospitalized patients with community-acquired pneumonia: an idea whose time has come. 885807-overview Vogtlander NP, Van Kasteren ME, Natsch S, et al. and What is the role of acyclovir (Zovirax) in intravenous-to-oral switch therapy? \�G&dd�N�����'�y�l�+ȑ��H�QͺѢ�! Elevated tacrolimus levels associated with intravenous azithromycin and ceftriaxone: a case report. (NDC 55390-612-10). Drummond MF, Becker DL, Hux M, et al. [Guideline] Sevinc F, Prins JM, Koopmans RP, et al. Ramírez JA; Community-Acquired Pneumonia Organization Investigators. Cunha BA. Please confirm that you would like to log out of Medscape. Parenteral-oral switch in the management of paediatric pneumonia. Early switch from intravenous to oral antibiotics and early hospital discharge: a prospective observational study of 200 consecutive patients with community-acquired pneumonia. Buyle F, Vogelaers D, Peleman R, Van Maele G, Robays H. Implementation of guidelines for sequential therapy with fluoroquinolones in a Belgian hospital. Acyclovir is widely used in the treatment of herpesvirus infections, particularly herpes simplex virus (HSV) and varicella-zoster virus (VZV). 300 Tri-State International Lincolnshire, Illinois, USA: Melinta Therapeutics, Inc. 6/2017. Schaeffer AJ. Finch R, Schurmann D, Collins O, et al. Effect of multifaceted intervention promoting early switch from intravenous to oral acetaminophen for postoperative pain: controlled, prospective, before and after study. All intravenous acyclovir Reason for shortage: The manufacturers provide no specific reasons for delays, and a projected release date is unknown. Conversion Based on specific indications [refer to dosing guide in www.lexicomp.com] clinical efficacy of oral acyclovir in high-risk immunocompromised patients is … Fischer MA, Solomon DH, Teich JM, Avorn J. Primary HSV infection-genital (Oral therapy): 200mg every 4 hours while awake (5 times/day) or 400mg orally three times daily for 10 days. 2002 informational and educational purposes only. stream On the problems of switching from intravenous to oral administration in drug treatment of endogenous depression--a placebo-controlled double- blind trial with doxepin. Carcao and colleagues noted that immunocompromised children are at risk for disseminated varicella infections and that standard treatment involves hospitalization and intravenous acyclovir for 7-10 days. Candel FJ, Peñuelas M. Delafloxacin: design, development and potential place in therapy. Caceres VM, Stange KC, Kikano GE, Zyzanski SJ. Early oral switch therapy in low-risk Staphylococcus aureus bloodstream infection (SABATO): study protocol for a randomized controlled trial. The Steroid Conversion Calculator converts steroid dosages using dosing equivalencies. Pea F, Ferrari E, Pavan F, Roman-Pognuz D, Bandello F, Furlanut M. Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery. Make this process part of your daily workflow. Wilcox MH. Bui K, Quintiliani R. Antimicrobial switch therapy. Strategies for early discharge of the hospitalized patient with community-acquired pneumonia. �@����n�'Q�>�w�+Ζ(��@����Sf$ ����&�bP8%�a?���/��w��k�ƋAڧ��-iL,���6���k���& The information provided acts as guide and should not replace individual clinical judgement Giamarellou H, Bassaris HP, Petrikkos G, et al. 20 mL sterile vials, each containing acyclovir sodium equivalent to 1000 mg of acyclovir, carton of 10. Halm EA, Switzer GE, Mittman BS, et al. Li JZ, Willke RJ, Rittenhouse BE, Rybak MJ. Cyriac JM, James E. Switch over from intravenous to oral therapy: A concise overview. Available at Baxdela (delafloxacin) [package insert]. Oosterheert JJ, Bonten MJ, Schneider MM, Buskens E, Lammers JW, Hustinx WM. Cunha BA. Predictors of symptom resolution in patients with community-acquired pneumonia. Oral antibiotic treatment of infectious diseases. Controlled studies in pregnant women show no evidence of fetal risk.Interferes with DNA polymerase to inhibit DNA replication via chain terminationDistributed widely (brain, kidney, lungs, liver, spleen, muscle, uterus, vagina, cerebrospinal fluid [CSF])Half-life: 4 hr (Neonates); 2-3 hr (children 1-12 years); 3 hr (adults)Y-site: Amifostine, amsacrine, aztreonam, cefepime, dobutamine, dopamine, fludarabine, foscarnet, gemcitabine, idarubicin, levofloxacin, morphine sulfate (? 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