What happens in myasthenia gravis is that the immune system hinders the neuromuscular impulses that are necessary for muscular function. [3]A woman who had taken oral acyclovir 400 mg 3 times daily for 3 days in the peripartum period had a breastmilk acyclovir level of 54 mcg/L at 5 days after her last dose of acyclovir. Monitor neutrophil count 2. The investigators study is a randomized, double- blinded placebo-controlled clinical trial in Amiralam Hospital. [PubMedFrenkel LM, Brown ZA, Bryson YJ et al. 0000016749 00000 n
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Myasthenia gravis (MG) is an autoimmune disorder affecting the voluntary muscles. 0000145787 00000 n
Monitor kidney function in patients with kidney impairment or those receiving potentially nephrotoxic drugs. 0000015882 00000 n
replication. Even with the highest maternal dosages, the dosage of acyclovir in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants. 0000014626 00000 n
Drug Name Generic Name : acyclovir (acycloguanosine) Brand Name: Alti-Acyclovir (CAN), Avirax (CAN), Zovirax Classification: Antiviral, Purine nucleoside analogue Pregnancy Category B Dosages & Route ADULTS Parenteral 5–10 mg/kg infused IV over 1 hr, q 8 hr (15 mg/kg/day) for 7–10 days. Use with caution in patients with hepatic/renal dysfunction or neurologic disease Nursing Implications 1. 0000011169 00000 n
Critical Thinking in the Nursing Process 1. Genital herpes: 1 g PO bid for 7–10 days. Our goal is to give you clear and concise information so you can enjoy your nursing journey. [PubMedBork K, Benes P. Concentration and kinetic studies of intravenous acyclovir in serum and breast milk of a patient with eczema herpeticum. These concentrations would potentially expose the nursing infant to a dose of acyclovir … 0000042182 00000 n
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transplant recipients, treatment of disseminated herpes zoster, immunocompromised patients, lactation. 2. 1994;28:585-7. • Mestinon Timespan® should never be crushed. 0000071247 00000 n
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• Mestinon Timespan® should never be substituted for regular Mestinon® or generic pyridostigmine. Monitor input and output closely 3. Monitor neutrophil count 2. Hypersensitivity to acyclovir 2. 0000134826 00000 n
Acyclovir concentrations have been documented in breast milk in 2 women following oral administration of ZOVIRAX (acyclovir) and ranged from 0.6 to 4.1 times corresponding plasma levels. Milk levels taken immediately before a dose during 5 days of therapy ranged from 0.78 to 1.07 mg/L. 0000002751 00000 n
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Following oral administration of acyclovir, breast milk concentrations 1- to 4-times that of those found in maternal plasma have been observed. Available for Android and iOS devices.Noti A, Grob K, Biedermann M et al. Mestinon Side Effects. < The peak level was 7.3 mg/L and the drug was detectable in milk for up to 88 hours after the last dose. 0000185467 00000 n
Safety and efficacy
Watch IV site for phlebitis - if noted, make infusion more dilute 4. 0000186851 00000 n
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[24464] These concentrations would potentially expose the nursing infant to a dose of acyclovir as high as 0.3 mg/kg/day. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 0000133356 00000 n
Instead, I … Metabolism: Rapidly converted to acyclovir during first pass through intestine and liver. 0000133422 00000 n
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