In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Nat. P values lower than 0.05 were considered to be significant.Mukhopadhyay, T., Sasaki, J., Ramesh, R. & Roth, J. However, searching for anticancer activity in compounds that have been “generally regarded as safe” may or may not turn up a promising drug suitable for GBM.Mebendazole (MBZ), methyl N-[6-(benzoyl)-1H-benzimidazol-2-yl] carbamate, is a drug developed to treat human helminthic infections. Clin. Chem. Clin. A multicolor panel of novel lentiviral “gene ontology” (LeGO) vectors for functional gene analysis. 8, 71 (2012).Dakshanamurthy, S. et al. Auch ihr wurden nur noch drei Monate Lebenszeit gegeben. Ma.M. (A) The half-maximal inhibitory concentration (ICMebendazole (MBZ) plus temozolomide (TMZ) extends survival further than TMZ alone in the GL261 mouse model. Cancer 10, 194–204 (2010).Dumontet, C. & Jordan, M. A. Microtubule-binding agents: a dynamic field of cancer therapeutics. Cells were seeded in 96-well cell culture plates and allowed to adhere overnight. 139, 2133–2140 (2013).Ceballos, L. et al. Dosing with a high-fat meal is known to modestly increase bioavailability [
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole and flubendazole in intestinal cancer cell lines. Rev. Cancer Gene Ther. Resistance acquisition is a major problem in high-risk neuroblastoma. All cells were maintained at 37°C in humidified air containing 5% COABZ, MBZ, thiabendazole, and fenbendazole were purchased from Sigma-Aldrich. Ein natürliches Mittel ist ein solches Wurmmittel jedoch nicht und passt daher im Grunde nicht zu unserem ganzheitlichen Konzept. Three and more groups were compared by ANOVA followed by the Student-Newman-Keuls test. Bei Hirntumoren wird häufig das Chemo-Medikament Vincristin eingesetzt. Subsequently, MBZ was shown to inhibit human melanoma xenograft growth in athymic female nude mice fed 1 mg or 2 mg oral MBZ every other day [
At 15 mg/kg, TMZ extended the survival rate by 41.4%. A., Booth-Genthe, C. & Gottesman, M. M. Targeting multidrug resistance in cancer. Clin Cancer Res. Screening of compounds for activity against colon cancer cell lines also identified MBZ as a candidate molecule in work by Nygren and colleagues [
You can also search for this author in In the case of long-term administration of MBZ for echinococcosis, the evidence is that, in general, the treatment is well tolerated, but the specific treatment for some patients has to be discontinued. The flubendazole-induced necrosis levels were higher in UKF-NB-3 and UKF-NB-3Flubendazole had been demonstrated to exert activity against leukaemia and myeloma cellsNeuroblastoma is the most frequent extracranial solid childhood tumour. The drugs listed below may also be suitable for combination treatments with MBZ and other agents, however, the evidence is not as strong and therefore this list must be viewed as more speculative. You can also search for this author in The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. The following drugs warrant further investigation in combination with mebendazole (MBZ), both in pre-clinical studies and potentially in clinical trials. Biometrics Bulletin 1, 80–83 (1945).Benjamini, Y. For example, in lung cancer cell lines, it was found that MBZ treatment caused post-translational p53 stabilization and the downstream expression of p21 and MDM2 [
Hypersensitivity reactions, such as rash, urticaria, and angioedema, have been observed on rare occasions. B. Vermicat oder Flubenol. Concentrations of 1 μM appear pharmacologically achievable based on prior studies in mice that demonstrated a dose of 5 mg/kg to produce a CEffects of flubendazole in a panel of cancer cell lines from different entities.The flubendazole concentrations that decreased cancer cell viability by 90% (ICAcquired resistance formation is a major problem in high-risk neuroblastomaEffects of flubendazole in a panel of parental neuroblastoma cell lines and their sub-lines adapted to anti-cancer drugs.The flubendazole concentrations that decreased cancer cell viability by 90% (ICThe majority (87, 62%) of the 140 drug-resistant neuroblastoma cell lines was similarly sensitive to flubendazole like the corresponding parental cell lines as indicated by fold changes ICIn concordance with its anticipated effects on microtubule functionPrimary neuroblastoma cells isolated from the bone marrow of five patients with metastasised INSS stage 4 disease showed similar flubendazole sensitivity like the investigated neuroblastoma cell lines.