Thank you for submitting a comment on this article. Yun Lu, Pharm.D., Katie A. If JT remains in AF, why would amiodarone be continued?
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Copyright © 2008, American Society of Health-System Pharmacists, Inc. All rights reserved. Department of Pharmacy, Hennepin County Medical Center (HCMC), Minneapolis, MN
JT is a 61 year old male. Won, Pharm.D., Brenda J. Nelson, Pharm.D., Dongfeng Qi, Ph.D., Douglas J. Rausch, M.D., Richard W. Asinger, M.D., Characteristics of the amiodarone–warfarin interaction during long-term follow-up, Most users should sign in with their email address.
14.Cheung B, Lam FM, Kumana CR… What really makes this unique is the long duration of action and half life of amiodarone. Beacuse JT has AF does not mean amiodarone will be effective. Clinical Pharmacy Education – Improving Practice, Protecting Patients between warfarin and amiodarone results in an increased warfarin effect. If you originally registered with a username please use that to sign in. Good information from the front lines of healthcare is really hard to find, and that is what I try to provide day after day. That half life is a real doosie, too. ASHP Statement on the Use of Artificial Intelligence in Pharmacy
– Another really important concept is DID AMIODARONE WORK? The amiodarone and warfarin interaction can be a little more challenging than other drug interactions. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription. Hematologist/Oncologist and Division Head
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To whom much is given, much is expected. Amiodarone — during the loading phase, check the international normalized ratio (INR) once a week and adjust the dose according to the INR. Please check your email address / username and password and try again. Seems like they taper the amiodarone over time in my experience. In fact, the mean dose of warfarin returned to near that of baseline values at the end of the 12-month study period. The interaction between amiodarone and warfarin has only been described in patients being followed up for relatively short time periods. Br J Clin Pharmacol 1984 Sep; 18(3):355-60. Don't already have an Oxford Academic account? Hospital Pharmacy Specialist in Hematology/Oncology
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Enjoy the blog? Although patients starting warfarin required more frequent dosage changes and had higher event rates, more patients receiving concurrent warfarin and amiodarone had an INR of >5 compared with patients on warfarin alone managed by the same clinic, suggesting that the drug interaction contributed to the higher event rate in this population. Similarly, when stopping amiodarone, the INR should be checked frequently and the dose adjusted as needed. There are several large, well-performed studies using genetic and clinical factors such as co-medi- cation to predict an adequate starting dose of warfarin. Check INR q1-2 weeks and make serial adjustments per INR. This article is also available for rental through DeepDyve. 13.Arboix M, Frati ME, Laporte JR. Amiodarone: slow ↑ over time: Complex interaction that takes place over 6-8 weeks. Oxford University Press is a department of the University of Oxford. Your comment will be reviewed and published at the journal's discretion. Hospital Pharmacy Specialist, Allina Pharmacy Service
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