Am Heart J 1994;128:884-91. CIMETIDINE The grapefruit juice was commercially prepared (REA jus de fruits, Sarre‐Union, France) and was all from the same preparation batch with a calibrated amount of flavonoids (nariturine: 135 mg lAll 12‐lead electrocardiograms were obtained by means of a paper ECG recorder (EK53 Helige cardiotest recorder) and were performed by the same research nurse throughout the study. Nevertheless, the use of calibrated lunches and of a 14 h fasting period preceding the evaluations should have reduced such variability.As grapefruit juice is already known to inhibit CYP3A4 activity, these results are in agreement with previous experimental data which have suggested that N‐DEA is produced mainly by the CYP3A4 in humans [Since the gut wall contains CYP3A4, it is highly probable that these inhibitors act, at least in part, on the prehepatic amiodarone biotransformation [In spite of the lack of statistically significant arterial pressure alterations and although the extent of the ECG changes observed in these healthy volunteers was not of concern, these changes could be important in patients suffering from cardiomyopathy and/or from conduction or rhythmic disorders. The simultaneous oral co-administration of C. aurantium extract and amiodarone induced a delay in the t max of the drug.. A 14-day oral pre-treatment with C. aurantium extract induced a significant increase in the C max of amiodarone.. A clinical examination was carried out and blood samples taken for thyroid hormone and amiodarone concentration measurements were carried out before inclusion in the study.Each subject was given one oral dose of amiodarone in 300 ml of grapefruit juice (as opposed to the water used in the first evaluation). The interactions between amiodarone and other drugs might occur via the inhibition of CYP activities by its N-dealkylated metabolite, desethylamiodarone, rather than by amiodarone itself. capsule, blue/white, imprinted with LOGO, R150. P450 CYP3A: possible involvement of non‐flavonoid components in drug interactionInactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juiceMechanism‐based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wineThe fate of naringin in humans: a key to grapefruit juice–drug interactions?A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patientAcute and chronic effects of amiodarone on ventricular refractoriness intraventricular conduction and ventricular tachycardia inductionEffect of amiodarone on conduction and refractoriness of the His‐Purkinje system in the human heartQT prolongation and the antiarrhythmic efficacy of amiodaronePharmacodynamics of intravenous amiodarone in the dogElectrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrationSerum concentrations of amiodarone during long term therapy: relation to dose, efficacy and toxicitySteady‐state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicityReview on Preclinical and Clinical Evidence of Food (Beverages, Fruits and Vegetables) and Drug Interactions: Mechanism and Safety, New‐onset postoperative atrial fibrillation after heart surgery, The role of amiodarone in contemporary management of complex cardiac arrhythmias, Nano-scale drug delivery systems for antiarrhythmic agents, Amiodarone Rifampicin Drug–Drug Interaction Management With Therapeutic Drug Monitoring, Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) ― Digest Version ―, Antiarrhythmic Drug Therapy for Atrial Fibrillation, A Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data, European Journal of Drug Metabolism and Pharmacokinetics, Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects, Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats, A CASE REPORT OF AMIODARONE INDUCED MYOPATHY IN A PATIENT OF VENTRICULAR ARRHYTHMIA, Journal of Evolution of Medical and Dental Sciences, An Updated Mini Review on Grapefruit: Interactions with Drugs, Obesity and Cardiovascular Risk Factors, Antiarrhythmic Drug Therapy for Atrial Fibrillation, Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions, Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects, Investigating herb–drug interactions: The effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats, Cardiovascular Therapeutics: A Companion to Braunwald's Heart Disease, Herb–drug interaction of Fucus vesiculosus extract and amiodarone in rats: A potential risk for reduced bioavailability of amiodarone in clinical practice, Improved Oral Bioavailability of BCS Class 2 Compounds by Self Nano-Emulsifying Drug Delivery Systems (SNEDDS): The Underlying Mechanisms for Amiodarone and Talinolol, A Rapid HPLC Method for the Simultaneous Determination of Amiodarone and its Major Metabolite in Rat Plasma and Tissues: A Useful Tool for Pharmacokinetic Studies,