In a long-term (follow-up at least 6 months, mean 13.8 months) placebo-controlled mortality/morbidity study of amlodipine besylate tablets 5-10 mg in 1153 patients with NYHA Classes III (n=931) or IV (n=222) heart failure on stable doses of diuretics, digoxin, and ACE inhibitors, amlodipine had no effect on the primary endpoint of the study which was the combined endpoint of all-cause mortality and cardiac morbidity (as defined by life-threatening arrhythmia, acute myocardial infarction, or hospitalization for worsened heart failure), or on NYHA classification, or symptoms of heart failure. If you have any questions about amlodipine besylate tablets, ask your doctor. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Amlodipine besylate tablets, USP are formulated as white tablets equivalent to 2.5 mg, 5 mg, and 10 mg of amlodipine for oral administration. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Do not store in the bathroom. Absolute bioavailability has been estimated to be between 64 and 90%. Store amlodipine besylate tablets at room temperature (store between 20° to 25°C (68° to 77°F). Sekilas Tentang Amlodipine Pada Amlodipine Besylate. Obat Amlodipine besylate ini digunakan untuk mengobati tekanan darah […] Search for: Artikel Terbaru. Efek samping ini dapat bervariasi pada setiap individu tergantung pada pada kondisi penyakit, usia, berat badan, jenis kelamin, etnis, maupun kondisi kesehatan seseorang. Increases in symptom-limited exercise time averaged 12.8% (63 sec) for amlodipine besylate tablets 10 mg, and averaged 7.9% (38 sec) for amlodipine besylate tablets 5 mg. amlodipine besylate tablets 10 mg also increased time to 1 mm ST segment deviation in several studies and decreased angina attack rate. There may be new information. The mean duration of follow-up was 19 months. Hexapharm, dan PT. 3 For the rat, the highest dose was, on a mg/m2 basis, about twice the maximum recommended human dose. Sometimes you can feel it in your shoulders, arms, neck, jaws, or back. obat ini tersedia dalam 2 jenis sediaan, yaitu amlodipine 5 mg dan 10 mg. amlodipine bekerja dengan cara melemaskan dinding pembuluh darah. In controlled clinical trials directly comparing amlodipine besylate tablets (N= 1730) at doses up to10 mg to placebo (N= 1250), discontinuation of amlodipine besylate tablets due to adverse reactions was required in only about 1.5% of patients and was not significantly different from placebo (about 1%). The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Ex vivo studies have shown that approximately 93% of the circulating drug is bound to plasma proteins in hypertensive patients. When amlodipine and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect.Co-administration of multiple 10 mg doses of amlodipine with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in 77 % increase in exposure to simvastatin compared to simvastatin alone. These decreases in blood pressure are not accompanied by a significant change in heart rate or plasma catecholamine levels with chronic dosing. Effects were similar in black patients and in white patients.Two hundred sixty-eight hypertensive patients aged 6 to 17 years were randomized first to amlodipine besylate tablets 2.5 or 5 mg once daily for 4 weeks and then randomized again to the same dose or to placebo for another 4 weeks. It may be used alone or in combination with other antihypertensive agents.Amlodipine besylate tablets, USP are indicated for the symptomatic treatment of chronic stable angina. In addition to the active ingredient, amlodipine besylate, USP each tablet contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, sodium starch glycolate, and magnesium stearate. For the mouse, the highest dose was, on a mg/m2 basis, similar to the maximum recommended human dose of 10 mg amlodipine/day. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. Pendaftaran obat pada Badan POM dilakukan oleh perusahaan obat tradisional dalam negeri yang telah mendapatkan persetujuan dari perusahaan pembuat obat tradisional asal luar negeri tersebut.Otto Pharmaceutical merupakan suatu perusahaan farmasi yang berdiri pada tahun 1963 di kota Bandung, Jawa Barat. 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