1997 Mar-Apr;NS37(2):157-63. doi: 10.1016/s1086-5802(16)30202-9.Gantt S, Cattamanchi A, Krantz E, Magaret A, Selke S, Kuntz SR, Huang ML, Corey L, Wald A, Casper C.J Clin Virol. Pediatr Infect Dis J. 2017 Nov 29;6(12):111. doi: 10.3390/jcm6120111.Yager JE, Magaret AS, Kuntz SR, Selke S, Huang ML, Corey L, Casper C, Wald A.J Infect Dis. This study will determine whether acyclovir, a medicine used to treat herpes simplex virus 2 (HSV-2), can slow down the progression (worsening) of HIV disease in people with both HIV and HSV-2 infections. COVID-19 is an emerging, rapidly evolving situation. eCollection 2016.Phipps W, Saracino M, Selke S, Huang ML, Jaoko W, Mandaliya K, Wald A, Casper C, McClelland RS.J Med Virol. In contrast, HAART was a potent inhibitor of HHV-8 replication. Neither antiviral nor antiretroviral therapy was associated with decreased HHV-8 quantity. ... Valacyclovir (prodrug of acyclovir with greater oral bioavailability) Penciclovir. 2016 Feb 10;11:7. doi: 10.1186/s13027-016-0052-2. Intravenous ZOVIRAX is indicated for the treatment of varicella-zoster infections in immunocompromised patients. Change in HHV-8 Oropharyngeal Detection Rates between Placebo and Antiviral Drug Arms, by ParticipantChange in HHV-8 Oropharyngeal Detection Rates by Highly Active Antiretroviral Therapy Use Daily oropharyngeal swabs were analyzed from HIV/HHV-8 dually infected men enrolled in three previous clinical trials of valacyclovir and famciclovir for HIV-1 and/or HSV-2 suppression. Name must be less than 100 characters The first antiviral drug to be approved for treating HIV, zidovudine (AZT), is also a nucleoside analogue. HHV-8 was detected in 1,128 (19%) of 6,036 swabs, including 618 (21%) of 2,992 on placebo, 323 (15%) of 2,221 on valacyclovir, and 187 (23%) of 823 on famciclovir. Free PMC article 1997 Sep;16(9):838-41. doi: 10.1097/00006454-199709000-00004.Wald A, Selke S, Warren T, Aoki FY, Sacks S, Diaz-Mitoma F, Corey L.Sex Transm Dis. Unable to load your collection due to an error 2017 Jul 15;216(2):198-202. doi: 10.1093/infdis/jix263.Int J Oral Sci. Free PMC article (2) Earlier studies during the era of zidovudine (Retrovir) monotherapy showed a survival advantage when acyclovir (ACV, Zovirax) was added to the treatment of patients with HIV. ... Antiretroviral therapy as HIV prevention You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more. The first antiviral drug to be approved for treating HIV, zidovudine (AZT), is also a nucleoside analogue. In Viral Pathogenesis (Third Edition), 2016. Suppressive aciclovir might be warranted for individuals dually infected with HSV-2 and HIV-1 with viral loads of 50,000 copies per mL or more before initiation of antiretroviral treatment. (1) This finding has been supported by clinical evidence that individuals who are HSV-2 seropositive at the time of HIV-1 seroconversion had higher HIV viral loads at 5 and 15 months post-seroconversion. 2014 Oct;86(10):1759-65. doi: 10.1002/jmv.23941. Clipboard, Search History, and several other advanced features are temporarily unavailable. HAART was associated with an 89% (IRR 0.129; P = 0.048) reduction in HHV-8-shedding. (3) Acyclovir prophylaxis has been shown to decrease herpes simplex virus infections and varicella-zoster virus infections among HIV infected patients in a meta-analysis of randomized trials from North America and Europe. acyclovir: Zovirax: For initial and recurrent mucosal and cutaneous HSV-1, HSV-2, and varicella-zoster infections in immunocompromised individuals. Two types of HSV can cause genital herpes: HSV-1 and HSV-2.