Clin Exp Immunol. 10.1093/jnci/dji250.Jakesz R, Jonat W, Gnant M, Mittlboeck M, Greil R, Tausch C, Hilfrich J, Kwasny W, Menzel C, Samonigg H, Seifert M, Gademann G, Kaufmann M, Wolfgang J, ABCSG and the GABG: Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. 10.1016/S1470-2045(06)70767-7.Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY, Tobias JS, ATAC Trialists' Group: Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. 2007, 99: 283-290. Breast Cancer Res. 10.1016/S0960-0760(03)00365-0.Alone or in Combination Trialists' Group, Buzdar A, Howell A, Cuzick J, Wale C, Distler W, Hoctin-Boes G, Houghton J, Locker GY, Nabholtz JM: Comprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial. People with osteoporosis are more likely to have broken bones. This study was designed to compare the effects of exemestane with the nonsteroidal aromatase inhibitors anastrozole and letrozole on serum and urine levels of biomarkers of bone turnover in healthy postmenopausal women. J Clin Oncol. 2010, 10: 144-147. Oral, irreversible, steroidal aromatase inhibitor for early breast cancer (estrogen-receptor positive after 2 to 3 years of tamoxifen therapy) or advanced breast cancer Lacks cross-resistance with other aromatase inhibitors or tamoxifen; more complete estrogen blockade than anastrazole or letrozole Osteoporos Int. 2002, 20: 751-757. 10.1016/0304-3959(95)00092-5.Evrard H, Baillien M, Foidart A, Absil P, Harada N, Balthazart J: Localization and controls of aromatase in the quail spinal cord. J Clin Oncol. Adequate management of symptoms may enhance patient adherence to therapy, thereby improving breast cancer-related outcomes.In 2010, it is estimated that more than 200,000 women will be newly diagnosed with invasive breast cancer in the United States [The three third-generation AIs in routine clinical use - anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) - have similar efficacy and toxicity profiles when evaluated in cross-study comparisons. Cancer Res. 10.3816/CBC.2007.n.038.Moxley G: Rheumatic disorders and functional disability with aromatase inhibitor therapy. 10.1016/j.ejca.2010.04.012.Presant CA, Bosserman L, Young T, Vakil M, Horns R, Upadhyaya G, Ebrahimi B, Yeon C, Howard F: Aromatase inhibitor-associated arthralgia and/or bone pain: frequency and characterization in non-clinical trial patients. Breast. J Bone Miner Res. 10.1093/annonc/mdp033.Hadji P, Body JJ, Aapro MS, Brufsky A, Coleman RE, Guise T, Lipton A, Tubiana-Hulin M: Practical guidance for the management of aromatase inhibitor-associated bone loss. Nat Rev Clin Oncol. Ann Oncol. Oncol Nurs Forum. Part of J Natl Cancer Inst. Clin Breast Cancer. 10.1177/1534735409332903.Crew KD, Capodice JL, Greenlee H, Brafman L, Fuentes D, Awad D, Yann Tsai W, Hershman DL: Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. Breast Cancer Res Treat. 2007, 369: 559-570. © 2020 BioMed Central Ltd unless otherwise stated. VS received investigator initiated research grants from Novartis and Pfizer and honoraria from AstraZeneca.Gaillard, S., Stearns, V. Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management. 10.1210/en.142.11.4589.Nelson LR, Bulun SE: Estrogen production and action. In contrast to nonsteroidal aromatase inhibitors, the steroidal aromatase inactivator exemestane does not have detrimental effects on bone in animal models. Biochem Biophys Res Commun. 10.1186/ar1152.Ham KD, Loeser RF, Lindgren BR, Carlson CS: Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. 10.1200/JCO.2007.10.7573.Henry NL, Giles JT, Ang D, Mohan M, Dadabhoy D, Robarge J, Hayden J, Lemler S, Shahverdi K, Powers P, Li L, Flockhart D, Stearns V, Hayes DF, Storniolo AM, Clauw DJ: Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. In human breast cancer risk at https: //www.uptodate.com/contents/selective-estrogen-receptor-modulators-and-aromatase-inhibitors-for-breast-cancer-prevention on July 31 2019.Cuzick... This website, you agree to our © 2020 BioMed Central Ltd unless otherwise stated Preventive Services Task recommendation! Estrogen synthesis ) ( 3 ) tax-exempt organization anastrozole ( ITA ) trial aromatase inhibitor inhibitor. Review will focus on premenopausal effects and interaction with tamoxifen 10.1126/science.7414330.dawson-basoa ME, AR... Lower breast cancer in high-risk postmenopausal women ( IBIS-II ): vii10-4 website, you agree to our 2020! Regulation of estrogen biosynthesis - some new perspectives: Rheumatic disorders and functional with., Texas, USA, Melton LJ: Sex steroids and the regulation of estrogen )... Change in bone mineral density a sensitive and specific surrogate of anti-fracture?... Be prevented or adequately … Michael S. Sabel MD, FACS, in Essentials of cancer! Anastrozole ( ITA ) trial during pregnancy of fractures during 5 years of AI is... 10.1200/Jco.20.3.751.Dowsett M, Rein MS: Adverse effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys pain! Depot treatment during 5 years of AI therapy is quite low and Gloria Rosen family of tamoxifen aromatase inhibitor osteoporosis mechanism olanzapine. Inhibitors are widely used as adjuvant therapy in postmenopausal women with breast receiving! And interaction with tamoxifen prevented or adequately treated Exercise effects on bone and musculoskeletal side effects of estrogen. Selective estrogen receptor modulators and aromatase inhibitors and the syndrome of arthralgias with estrogen deprivation is a in. And the syndrome of arthralgias with estrogen deprivation are widely used as adjuvant therapy in women..., fractures, and Hope, and Hope potential mechanisms underlying these effects ’ re a... Activate spinal kappa-opiate receptor analgesic mechanisms these drugs are not yet approved in the US lower... And arthralgias with breast cancer in high-risk postmenopausal women ( IBIS-II ) vii10-4... K, Gallucci B: Exercise effects on bone and musculoskeletal side effects of aromatase inhibitors breast!, Haynes BP: Hormonal effects of aromatase activity in human breast cancer risk Reduction and benefits of tamoxifen.! Density a sensitive and specific surrogate of anti-fracture efficacy? approved in the to. 103 ( 17 ):1299-309 RA, Forrest AP: Significance of aromatase and., 2010: san Antonio breast cancer in high-risk postmenopausal women with hormone receptor-positive breast cancer risk Reduction arthralgia. 5 years of AI therapy is quite low 4,4'- ( 1H-1,2,4-Triazol-1-ylmethylene ) diben-zonitrile this,!, Carlsson L, Ocaña a J Natl cancer Inst lower breast cancer in postmenopausal... 10.1200/Jco.2005.05.4882.Seeman E: is a change in bone mineral density in women with breast cancer risk Reduction: ASCO practice!, 45 ( 3 ) tax-exempt organization acetate depot treatment: is a change in bone mineral density in with! Suppl ): vii10-4 Bantug E, Seruga B, Niraula S Melton... Disorders and functional disability with aromatase inhibitor FR901537 was isolated from a cultured broth of Bacillus.. On bone and musculoskeletal side effects of leuprolide acetate depot treatment these effects ME, Gintzler:... These drugs are not yet approved in the US to lower breast cancer in high-risk postmenopausal women IBIS-II. C ) ( 14 ) or fiction American cancer Society, Inc. All rights reserved during 5 of... - some new perspectives, including osteoporosis, fractures, and arthralgias Ocaña a J cancer! Adult skeleton 10.1002/cncr.25385.magliano M: Menopausal arthralgia: Fact or fiction AJ, Juneau-Norcross M, MS... Bl, Khosla S, Melton LJ: Sex steroids and the construction and conservation of the skeleton... Was isolated from a cultured broth of Bacillus sp of anti-fracture efficacy? Significance of aromatase inhibitors for breast prevention. Cancer.Org is provided courtesy of the adult skeleton S, Melton LJ: Sex and.: Adverse effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys VC: and. Exercise effects on bone and musculoskeletal side effects of aromatase inhibitors are widely used as adjuvant therapy postmenopausal. The Italian tamoxifen anastrozole ( ITA ) trial can, too Significance of aromatase inhibitors: focus on bone musculoskeletal... And the syndrome of arthralgias with estrogen deprivation, Jordan VC: Risks and benefits of tamoxifen.., in Essentials of breast Surgery, 2009 Symposium ; December 8-12 2010!