Barry, j. D. However, many people have no side effects or only have minor side effects. Second-line treatment includes mycophenolate mofetil (CellCept, Genentech) instead of azathioprine. 1). Finally, we skip immunosuppressive treatment since it has been described an increased tumor risk under azathioprine therapy, especially in Vogt-Kaganayi-Harada (VKH) syndrome. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, Pharmacology biochemistry and behavior 25, 749 763. Drug interactions are reported among people who take Imuran and Ibuprofen together. help if any of these side effects or any other side effects bother you or do not go away: “Was on Azathioprine for 4-5 years it got my liver numbers down and kept them down. Further metabolism occurs through competing pathways by three different enzymes: XO oxidizes 6MP into the inactive thiouric acid; HPRT converts 6MP into thioinosine monophosphate, of which further intracellular metabolism results in the formation of the active metabolite, TGN; TPMT methylates 6MP into the inactive methylmercaptopurine. However, budesonide is clearly less toxic.It is very important that practitioners monitor patients in remission closely to avoid any risks and complications. Call your doctor or get medical Clinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomLiver Unit, Royal Hallamshire Hospital, Sheffield, United KingdomClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United KingdomFinancial support for the laboratory consumables used in this study was provided by Bardhan Research and Education Trust of Rotherham Ltd. 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