Gastroenterology.
AZA has been shown to maintain remission and reduce corticosteroid use in patients with Crohn's disease. Inform your doctor if you experience signs of infection such as fever, chills and aches.
If you log out, you will be required to enter your username and password the next time you visit.
“I've had Crohn's Disease for 43 years and have been on everything. Note: historically, they have prescribed a low dose, 50mg I believe.
provider for the most current information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information. COMPARISON: Three different doses of azathioprine will be compared in this study (0.5, 2.5, and 3.5mg/kg/day). Studies: 1.5 to 4 mg/kg per day for 10 days up to 52 weeks
Imuran, also known by its drug name, Azathioprine, is a prescription medication approved by the Food and Drug Administration (FDA) in 1968 to help prevent rejection in people who had kidney transplants.
It is an antimetabolite which blocks the synthesis of purine, a protein the body needs in order to produce lymphocytes. Applies to the following strengths: 50 mg; 100 mg; 75 mgInitial dose: 3 to 5 mg/kg orally or IV once a day, beginning at the time of transplantInitial dose: 1 mg/kg (50 to 100 mg) orally or IV per day given in 1 to 2 divided dosesInitial dose: 3 to 5 mg/kg orally or IV once a day, beginning at the time of transplantLower doses may be required; however, no specific guidelines have been suggested.Dose adjustments may be required; however, no specific guidelines have been suggested.Dosage reduction or alternative therapy may be required in patients with reduced thiopurine S-methyltransferase (TPMT) activity.Data not available; approximately 45% of an azathioprine dose is removed by hemodialysis.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
It has never, ever, ever done anything for me. The study by Neurath et al compared the effect of MMF 15 mg/kg daily with azathioprine 2.5 mg/kg daily, both with high dose steroids, in the treatment of active chronic Crohn's disease (six months' follow up). Controlled studies in pregnant women show no evidence of fetal risk.Purine antimetabolite, converted to 6-MP; may inhibit synthesis of DNA, RNA, and proteins; interferes with cellular metabolism; may inhibit mitosisHalf-life: Parent drug, 12 min; 6-MP, 0.7-3 hr; slightly prolonged in end-stage renal diseaseOral suspension of 50 mg/mL requires extemporaneous compounding by pharmacistStable in neutral or acid solutions; in alkaline solutions, hydrolyzed to 6-MPCan be administered by IV push over 5 minutes at concentration not exceeding 10 mg/mLCan be further diluted with NS or D5W and administered by intermittent infusion over 30-60 minutes (usual approach); however, infusions over periods ranging from 5 minutes to 8 hours have been doneStore powder at room temperature (25°C); reconstituted solution is stable for 2 weeks at room temperature but may be less stable under refrigerationBecause there are no preservatives, drug must be used within 24 hoursAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Humira® Recommended Dosing for CD: 160 mg initially on Day 1 (given in 1 day or split over 2 consecutive days), followed by 80 mg 2 weeks later (Day 15).
More recently, it has been used to treat autoimmune diseases including inflammatory bowel diseases (IBD) such as Crohn’s disease and colitis.