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Attention to drug interactions, dosing adjustment in the context of organ dysfunction, and familiarity with FDA product labeling will decrease the probability of cardiac toxicity.Oxford University Press is a department of the University of Oxford. (voriconazole) for infusion, Pfizer Global Research and Development. Hydroxychloroquine, an analogue of chloroquine, was developed in 1946. Drug interactions of clinical significanceVoriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effectA case of pulmonary aspergillosis effectively treated with itraconazole: possible interaction of the antimycotic agent with hydroquinidine [in Italian]Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptylineVoriconazole—better chances for patients with invasive mycosesCardiac arrest associated with combination cisapride and itraconazole therapyProbable case of torsades de pointes induced by fluconazoleItraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardiaSyncopes during simultaneous use of terfenadine and itraconazole [in Dutch]Combined use of astemizole and ketoconazole resulting in torsade de pointesLong QT syndrome and torsade de pointes in a patient receiving fluconazoleTorsades de pointes after treatment with terfenadine and ketoconazoleNDA 21-266, Vfend (voriconazole) tablets, and NDA 21-267, Vfend I.V. Amoxicillin served as a control. Side effects with azithromycin are less frequent (<1%) and are usually mild. J Interv Card Electrophysiol 2007 ;18: 243 - 246 Crossref An imbalance of literature exists for newer drugs compared with older ones, primarily because of recent advances in study methodologies and recent regulatory scrutiny making comparisons between antimicrobials exceedingly difficult. Proposed for the treatment of invasive aspergillosis, serious Pentamidine reduces hERG expression to prolong the QT intervalInhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cellsRelationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development© 2006 by the Infectious Diseases Society of America
Department of Clinical Pharmacy Services, Divisions of Infectious DiseasesDepartment of Clinical Pharmacy Services, Divisions of Infectious DiseasesDepartment of Medicine, University of Vermont, College of Medicine
Although, in most cases, mild delays in ventricular repolarization caused by these drugs are clinically unnoticable, they may serve to amplify the risk for torsades de pointes (TdP) when prescribed in the setting of other risk factors.
Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, in addition to malaria. Events of interest included death and TdP/QT prolongation as well as accidents/injuries and depression as control events. You have entered an invalid code
Thank you for submitting a comment on this article. Combinations of hydroxychloroquine (HCQ) and azithromycin have been promoted as treatments for COVID-19 based on small, uncontrolled clinical trials that have not assessed potential risks. Herein, we review the mechanisms and risks for TdP and provide an overview of the antimicrobial agents marketed in North America that are associated with QT interval prolongation . Department of Clinical Pharmacy Services, Divisions of Infectious DiseasesNephrology and Transplantation, Maine Medical CenterDepartment of Medicine, University of Vermont, College of Medicine
The PRRs and 95% CIs for TdP/QT prolongation was 1.43 (1.29–2.59) with HCQ/CQ use alone and 4.10 (3.80–4.42) for azithromycin alone. Importantly, because ICH standardization documents for cardiac risk assessment were published in November 2005, robust comparative data for most antimicrobials do not exist. The human ether-à-go-go–related gene (hERG) encodes the rapid component of the delayed rectifier potassium current (IMethods to correct for some of the variability inherent in QT interval—chiefly, heart rate—do exist.