A sensitization reaction may manifest simply, as a failure to heal. This medication is for use on the skin only. Bacitracin Zinc and Polymyxin B Sulfate ophthalmic ointment USP, sterile, each gram contains bacitracin zinc equal to 500 bacitracin units and polymyxin B sulfate equal to 10,000 polymyxin B units, in a tube of 3.5 g (1/8 oz) with ophthalmic tip. 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. As with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment, USP is supplied in a tube of 1/8 oz (3.5 g) with an ophthalmic tip (NDC 57237-129-53). No adverse effects on male or female fertility, litter size, or survival were observed in rabbits given bacitracin zinc 100 gm/ton of diet.Animal reproduction studies have not been conducted with polymyxin B sulfate or bacitracin. Topical antibiotics may cause cutaneous sensitization. The eye ointment is used to treat some types of eye infections such as conjunctivitis. Get help now: If purulent discharge, inflammation, or pain become aggravated, the patient should discontinue use of the medication and consult a physician.There have been reports of bacterial keratitis associated with the use of topical ophthalmic products in multiple-dose containers which have been inadvertently contaminated by patients, most of whom has a concurrent corneal disease or a disruption of the ocular epithelial surface (see Allergic cross-reactions may occur which could prevent the use of any or all of the following antibiotics for the treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin.Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye, eyelid, fingers, or any other surface. Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment should never be directly introduced into the anterior chamber of the eye. Ask a doctor or pharmacist if it is safe for you to use this medicine if you are not sure. For the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by organisms susceptible to bacitracin zinc and polymyxin B sulfate. Apply the ointment every 3 or 4 hours for 7 to 10 days, depending on the severity of the infection. The use of this product by more than one person may spread infection.Patients should also be instructed that ocular products, if handled improperly, can become contaminated by common bacteria known to cause ocular infections. If superinfection occurs, appropriate measures should be initiated. Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment is a sterile antimicrobial ointment for ophthalmic use. Serious damage to the eye and subsequent loss of vision may result from using contaminated products (see If the condition persists or gets worse, or if a rash or allergic reaction develops, the patient should be advised to stop use and consult a physician. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Each gram contains: bacitracin zinc equivalent to 500 bacitracin units, polymyxin B sulfate equivalent to 10,000 polymyxin B units, mineral oil, and white petrolatum.Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the Polymyxin B sulfate is the sulfate salt of polymyxin BA wide range of antibacterial action is provided by the overlapping spectra of bacitracin and polymyxin B sulfate. 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