Triamcinolone acetonide cream and Celestone (betamethasone) are corticosteroids used to relieve skin inflammation, itching, dryness, and redness. It may harm them. Some of the topical corticosteroids and their metabolites are also excreted into the bile.Long-term animal studies have not been performed to evaluate the carcinogenic potential of betamethasone dipropionate.Betamethasone was negative in the bacterial mutagenicity assay Studies in rabbits, mice, and rats using intramuscular doses up to 1, 33, and 2 mg/kg, respectively, resulted in dose-related increases in fetal resorptions in rabbits and mice.The safety and efficacy of betamethasone dipropionate cream (augmented), 0.05% for the treatment of corticosteroid-responsive dermatoses have been established in two randomized and active controlled trials in subjects with chronic plaque psoriasis. The results show betamethasone valerate ointment to be significantly (P less than.05) s … The results suggested that the drug lowered adrenal corticosteroid secretion, although plasma cortisol levels did not go below the lower limit of the normal range.In an open-label pediatric trial of 60 evaluable subjects (3 months to 12 years of age), 19 subjects showed evidence of HPA axis suppression. Cataracts and glaucoma have been reported postmarketing with the use of topical corticosteroid products, including betamethasone dipropionate cream (augmented), 0.05% Avoid contact of betamethasone dipropionate cream (augmented), 0.05% with eyes. Clipboard, Search History, and several other advanced features are temporarily unavailable. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. In the light of publications from other studies on betamethasone valerate cream this trial indicates that the ointment base considerably increases the efficacy of betamethasone valerate.Munro DD, Robinson TWE, du Vivier AWP, France DM, Clayton R, Sparkes CG. Unable to load your delegates due to an error Being occlusive, an ointment will allow the medication to enter the skin more completely than a cream. At 7 g per day (3.5 g b.i.d. Acta Derm Venereol Suppl (Stockh). In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.Topical corticosteroids, such as betamethasone dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. Betamethasone rated 6.3/10 vs Triamcinolone rated 7.4/10 in overall patient satisfaction. Compare Betamethasone vs Triamcinolone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. ), Augmented Betamethasone Dipropionate Ointment was shown to cause minimal inhibition of the hypothalamic-pituitary-adrenal (HPA) axis when applied two times daily for 2 to 3 weeks, in normal patients and in patients with psoriasis and eczematous disorders.With 6 g to 7 g of Augmented Betamethasone Dipropionate Ointment applied once daily for 3 weeks, no significant inhibition of the HPA axis was observed in patients with psoriasis and atopic dermatitis, as measured by plasma cortisol and 24-hour urinary 17-hydroxy-corticosteroid levels.Augmented Betamethasone Dipropionate Ointment is indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Augmented Betamethasone Dipropionate Ointment is contraindicated in patients who are hypersensitive to betamethasone dipropionate, to other corticosteroids, or to any ingredient in this preparation.Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.Conditions which augment systemic absorption include the application of the more potent corticosteroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.