Clarithromycin is a macrolide antibiotic. In all species the liver was the primary target organ at toxic doses. Doses of clarithromycin greater than 1000 mg per day should not be co-administered with protease inhibitors.Caution is advised regarding the concomitant administration of clarithromycin and calcium channel blockers metabolized by CYP3A4 (e.g. 250 mg once daily or 250 mg twice daily in more severe infections. Concomitant administration of clarithromycin (500 mg twice daily) and saquinavir (soft gelatin capsules, 1200 mg three times daily) to 12 healthy volunteers resulted in steady-state AUC and C Patients taking oral contraceptives should be warned that if diarrhoea, vomiting or breakthrough bleeding occur there is a possibility of contraceptive failure.The safety of clarithromycin for use during pregnancy has not been established. Dated March 2019. In one study in 14 healthy volunteers, the concomitant administration of clarithromycin and terfenadine resulted in 2- to 3-fold increase in the serum level of the acid metabolite of terfenadine and in prolongation of the QT interval which did not lead to any clinically detectable effect. However, for patients with renal impairment, the following dosage adjustments should be considered: For patients with CLSimilar dose adjustments should be considered in patients with reduced renal function when ritonavir is used as a pharmacokinetic enhancer with other HIV protease inhibitors including atazanavir and saquinavir (see section below, Bi-directional drug interactions)Co-administration of clarithromycin, known to inhibit CYP3A, and a drug primarily metabolised by CYP3A may be associated with elevations in drug concentrations that could increase or prolong both therapeutic and adverse effects of the concomitant drug. The most common are diarrhoea, feeling sick (nausea), tummy (abdominal) discomfort, and unusual tastes.Clarithromycin is prescribed to treat bacterial infections such as Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last?Coronavirus: what are asymptomatic and mild COVID-19?Coronavirus: what are moderate, severe and critical COVID-19?What are the differences between colds, flu and COVID-19?Are any coronavirus home remedies safe or effective?COVID-19: how to tell hay fever and coronavirus apartIs losing your sense of taste and smell a symptom of coronavirus?Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. and Spraque-Dawley (p.o. Clarithromycin is excreted into human breast milk. $14.93 $ 14. Other tissues less commonly affected included the stomach, thymus and other lymphoid tissues and the kidneys. You can opt out at any time or find out more by reading our Never give it to other people even if their condition appears to be the same as yours.If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.Do not keep out-of-date or unwanted medicines. The major clinical signs at toxic doses included emesis, weakness, reduced food consumption and weight gain, salivation, dehydration and hyperactivity. Drug delivery of midazolam via oromucosal route, which could bypass pre-systemic elimination of the drug, will likely result in a similar interaction to that observed after intravenous midazolam rather than oral administration. Since the microbiological activities of clarithromycin and 14-OH-clarithromycin are different for different bacteria, the intended therapeutic effect could be impaired during concomitant administration of clarithromycin and enzyme inducers.Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, 14-OHclarithromycin, were increased. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme.Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. At a massive dose of 400mg/kg/day, some dogs and monkeys developed corneal opacities and/or oedema.Fertility and reproduction studies in rats have shown no adverse effects.