As you may well know, "California rocket fuel" is a psychiatric slang for the combination of mirtazapine and venlafaxine. Nerve cells (neurons) communicate with other neurons via connections known as synapses. This website is supported by different affiliates and we receive a paid commission on certain products from our advertisers. At first I was moody, irritable but the other day everything seemed, well great. Pharmacodynamically, it functions primarily as a serotonin-norepinephrine reuptake inhibitor (SNRI) and is understood to be the first-ever “dual reuptake inhibitor” approved by the FDA for the treatment of major depressive disorder. Norepinephrine works primarily to increase arousal, cognitive function, attention, and alertness. The neuron sending the signal is referred to as presynaptic, and the neuron receiving the signal is referred to as postsynaptic. Copyright @2019 Privacy Policy. Pardon The Dust On Our Portal! The products and supplements mentioned on this site are not intended to diagnose, treat, cure, alleviate or prevent any diseases. The association venlafaxine-mirtazapine is currently known as California Rocket Fuel (CRF). We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. Nevertheless, the role of norepinephrine in the California Rocket Fuel cocktail is crucial. It would've been a good combination to try were you to get the Effexor up to at least 150-225 mg (where it starts to actually act as an SNRI). Author, The Female BrainMirtazapine Augmentation: Running Low on Rocket Fuel "For years, [California psychopharmacologist] Dr. Steven Stahl has said that the combination of mirtazapine and venlafaxine is 'California rocket fuel,' but I wasn't aware of any controlled trial looking at that. Studies show advantage in terms of efficacy and rapid control of depressive symptoms compared to other associations. A total of 44% experienced some adverse effects with sedation (19%) and weight gain (19%) most frequent. Arguably the best nootropic for this is St. John’s wort, which contains active compounds calledhypericin and hyperforin that appear to act as natural serotonin reuptake inhibitors.We suggest starting with a milder norepinephrine enhancer, such as acetyl-L-carnitine (ALCAR) or even Rhodiola roseaIf you find you still face side effects like drowsiness and lack of energy, then L-Dopa might be the better option to finish off your natural California Rocket Fuel stack. But don’t worry, we will make Remeron simple to understand. While your physician should never prescribe a dose high enough to cause serotonin syndrome, the risk of it is higher when using combo therapy like California Rocket Fuel.After weighing all the pros and cons of Remeron and Effexor, it stands to reason that most people should try natural alternatives to California Rocket Fuel first (or even as a way to come off both drugs). Introduction. They say that mirtazapine is very fast acting and I can vouch for that. This is due to their selective mechanisms as both serotonin and norepinephrine modulators.Effexor is a potent SSNRI, which means it inhibits reuptake (recycling) of serotonin and norepinephrine in your brain cells/neurons. We realize that’s a mouthful of scientific mumbo-jumbo for most people. All articles on this website are the opinions of their respective authors who do not claim or profess to be medical professionals providing medical advice. 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