Its from the caffeine in the medicine. Plus, once you start taking them, any headaches you do have may be less severe. Excedrin Migraine should be back on the market in October, according to the manufacturer. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If one doesn't help withing an hour, take another 1/2 a pill. I had a really bad migraine a few weeks ago and I took 1 1/2. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Just be sure to read the ingredients on the label to make sure you are getting the combination you desire. If experienced, these tend to have a Less Severe expressionIf experienced, these tend to have a Severe expressionIf experienced, these tend to have a Less Severe expressionIf experienced, these tend to have a Severe expressionIf experienced, these tend to have a Less Severe expressionSelected from data included with permission and copyrighted by First Databank, Inc. That's why you should only take 1. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.benzoic acid, D&C yellow #10 aluminum lake, disodium EDTA, FD&C blue #1, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, ferric oxide, gelatin, glycerin, hydroxypropylcellulose, hypromellose, isopropyl alcohol, lactose monohydrate, light mineral oil, maltitol solution, medium-chain triglycerides, microcrystalline cellulose, pepsin, polysorbate 20, povidone, propyl gallate, propylene glycol, simethicone emulsion, sorbitan monolaurate, stearic acid, titanium dioxideAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Gavreto (pralsetinib) is an oral selective RET kinase inhibitor for the...Onureg (azacitidine) is a nucleoside metabolic inhibitor indicated for the...Qdolo (tramadol hydrochloride) is an opioid agonist indicated in adults for ...Xaracoll (bupivacaine hydrochloride) is a fully bioresorbable collagen implant...The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It was pulled temporarily while the company addressed quality control problems. The study is created by eHealthMe based on reports of 367 people who take Zyrtec and Excedrin from the FDA, and is updated regularly. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children. I can't take regular Excedrin with the aspirin because it upsets my stomach. Available for Android and iOS devices.GlaxoSmithKline Consumer Healthcare Holdings (US) LLC Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … If I take 2, it makes me to shaky. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age. Allergy shots can help cut back on migraine headaches. There are quite a few other options for headache relief. Drug interactions are reported among people who take Zyrtec and Excedrin together. DO NOT USE IF INNER FOIL SEAL IMPRINTED WITH “SEALED for YOUR PROTECTION” IS BROKEN OR MISSINGWe comply with the HONcode standard for trustworthy health information - Taking 2 will make you jumpy and your heart races. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Select one or more newsletters to continue. This is because phenylephrine and the caffeine in excedrin can cause you to stay awake more than usual. Even over-the-counter drugs can make a difference when it comes to migraine triggers. Many patients do not disclose to their doctor how much medication they are taking and may be surprised to learn that their body has become physically dependent on, for example, a caffeine-based analgesic such as Excedrin.