Serum levels were monitored to identify interactions between CBD and AEDs. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include: Steroids; HMG CoA reductase inhibitors; Calcium channel blockers; Antihistamines; Prokinetics; HIV antivirals; Immune modulators These medications are presented in alphabetical order and primarily identify the cannabinoid as a PRECIPITANT medication that either INHIBITS, INDUCES, or competes as a SUBSTRATE for a specific enzyme/receptor of an OBJECT (OTHER) medication.We ask that if these above-mentioned drug-drug interaction lists are replicated for useThe associated datasets reported in this website and manuscript have been deposited and can be accessed in Penn State ScholarSphere _____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________Med Cannabis Cannabinoids 2020. doi: 10.1159/000507998______________________________________________________________________________________________________________________________________________________________________________ Although regulatory agency approved prescribing information is often the initial source of information when identifying potential drug-drug interactions, it may only provide for a limited number of exemplars or only reference a class of medications without providing any specific medication examples. Both cannabidiol and buprenorphine can have CNS depressant effects, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). Methods: In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day … eHealthMe has been monitoring drugs since 2008. Also, as newer medications are approved, and real-world evidence accumulates, another objective is to routinely update this drug-drug interaction list. * Approximation only. Buprenorphine. Objective: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. In addition to the list of NTI medications, we have identified a comprehensive list of 139 medications that could have a potential drug-drug interaction with a cannabinoid (prescription, OTC, or illicit). Clin Pharmacol Drug … All rights reserved. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drug interactions are reported among people who take Strattera and Cannabis together. A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects. Drugs that Interact with Cannabidiol. The SPC for Epidyolex ® advises that cannabidiol is used with caution in patients with moderate or severe hepatic impairment and recommends a lower starting dose in these patients. Carbamazepine. The following cannabinoid drug-drug interaction information is predicated on regulatory agency approved cannabinoid manufacturer prescribing information, and then supplemented with the FDA We have identified a list of 57 prescription medications displaying a narrow therapeutic index that are potentially impacted by concomitant cannabinoid use (whether through prescription use of cannabinoid medications or recreational/medical use of cannabis and its extracts). Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. The study is created by eHealthMe based on reports of 9 people who take Strattera and Cannabis from the Food and Drug Administration (FDA), and is updated regularly. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep … Med Cannabis Cannabinoids 2020. doi: 10.1159/000507998 Carbamazepine is predicted to decrease the exposure to cannabidiol. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Readers should consult the UKMi Q&A Cannabis based medicinal products potential drug interactions for further information on potential drug interactions. The study is created by eHealthMe based on reports of 9 people who take Strattera and Cannabis from the FDA, and is updated regularly. Cannabidiol and Tacrolimus: A Case Report Leino A, Emoto C, Fukuda T, Privitera M, VinksA, Alloway R. Evidence of a Clinically Significant Drug -Drug Interaction between Cannabidiol … Drug interactions are reported among people who take Strattera and Cannabis together. However, with the recent deregulation of CBD oil (hemp oil) and the steady increase in states and countries that have legalized recreational and medical marijuana, these products are often not associated with regulatory agency approved prescribing information.Penn State College of Medicine, Dept of Pharmacology One of the objectives of this website, and associated journal article, is to develop a comprehensive and detailed cannabinoid drug-drug interaction list aligned with regulatory approved prescribing information.