Name must be less than 100 characters Her CDI was safely managed with oxcarbazepine in place of DDAVP. Oral carbamazepine has been shown to have antidiuretic activity in seven out of nine patients with neurohypophyseal diabetes insipidus. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. Epilepsia. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. Usage and distribution for commercial purposes requires written permission.
Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. A link to reset your password has been sent to your e-mail address. PMID: 683972 No abstract available. [Article in Russian] Author A M Kaĭlakov.
Current Issue. Her serum sodium (SNa) level was 133 mEq/L (mmol/L) and her oxcarbazepine level was 21 μg/mL (therapeutic range 10–35 μg/mL). Whether or not oxcarbazepine could also be a therapy for nephrogenic diabetes insipidus (NDI) needs to be further examined. Only one study reported an increase in plasma ADH activity during carbamazepine therapy [Moreover, in a recent study of rat inner medullary collecting ducts, carbamazepine was shown in vitro to enhance free water permeability in the absence of ADH through an increase in aquaporin-2 (AQP2) expression in both normal collecting ducts and in collecting ducts in rats with lithium-induced nephrogenic DI via action on the V2 receptor-G protein complex [Our case report is the first clinical evidence to show that oxcarbamazepine can induce hyponatremia in a human subject either independent of ADH or at clinically undetectable ADH levels and that it may be an alternative therapy to DDAVP in patients with CDI. Der Diabetes insipidus ist eine Krankheit, die sich in einem Mangel des Hormons ADH (Antidiuretisches Hormon) äußert und infolgedessen die Funktionsfähigkeit der Nieren beeinträchtigt. Renaler Diabetes insipidus Sensitivität: 100% Spezifität: 100%. Zentraler Diabetes insipidus totalis Sensitivität: 95% Spezifität: 100%. Unable to load your collection due to an error 2002 May;51(5):613-20. doi: 10.1002/ana.10190.Kamiyama T, Iseki K, Kawazoe N, Takishita S, Fukiyama K.J Pediatr Endocrinol Metab. At the doses used side-effects were not a major problem. Weitere Abklärung im Durstversuch bei inadäquat erhöhter Serumosmolalität erforderlich. The SNa fell to 131 mEq/L (Table A summary of medication adjustments and associated pertinent serum and urine laboratory valuesA repeat serum ADH level was obtained 2 weeks following discharge and it was again undetectable (<0.5 pg/mL), which correlated with a serum osmolality of 288 mosm/kg and SNa of 137 mEq/L. MUCOSAL ADHERENCE OF HUMAN ENTEROPATHOGENIC ESCHERICHIA COLIDIAGNOSIS OF HIRSCHSPRUNG'S DISEASE BY QUANTITATIVE BIOCHEMICAL ASSAY OF ACETYLCHOLINESTERASE IN RECTAL TISSUE PDF | Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. S. Karger AG, Basel, Switzerland Five years later, the patient has remained off DDAVP with oxcarbazepine as the sole therapy controlling her epilepsy and CDI.The development of severe hyponatremia in this patient was completely unexpected and atypical of patients with CDI who usually present with polyuria and hypernatremia. JÁNOS P. RADÓ 1 Isotopic Department and Metabolic Unit, János Hospital Budapest, Hungary. The antidiuretic effect of carbamazepine was first described in 1966 when a beneficial effect of carbamazepine in controlling polyuria was observed in a patient with CDI [There have been several proposed mechanisms for carbamazepine-induced hyponatremia. The diuresis did not change in ADH-resistant diabetes insipidus patients. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. This site is protected by reCAPTCHA and the Google
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