12. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. 2014;168:729-36. Knott C, Reynolds F, Clayden G. Infantile spasms on weaning from breast milk containing anticonvulsants. The latter mother was also taking ethosuximide and clonazepam. Kacirova I, Grundmann M, Brozmanova H. Therapeutic monitoring of carbamazepine concentrations in breastfeeding mothers, maternal milk and nursed infants. 2000;37 (Pt 2):210-5. Carbamazepine passes through human breast milk and may potentially cause serious side effects in your baby. Maternal co-administration of enzyme-inducers decreased the value of the carbamazepine infant/maternal serum concentration ratio. sulfamethoxazole-trimethoprim oral brand names and other generic formulations include:. In 31 infants who also had serum carbamazepine epoxide measured, levels ranged from 0.0 to 0.6 mg/L. Accessed June 13, 2007. 1988;110:1195-205. Kaneko S, Sato T, Suzuki K. The levels of anticonvulsants in breast milk. Letter. In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. Some other anticonvulsants (e.g., phenytoin, carbamazepine) stimulate the metabolism of other drugs including anticonvulsants, whereas others (e.g., valproic acid) inhibit the metabolism of other drugs. 1984;6:266-71. Carbamazepine milk levels averaged 1.9 mg/L (range 0.8 to 3.8 mg/L), while maternal serum levels averaged 4.3 mg/L[5] An epileptic woman was taking carbamazepine 1 g daily and primidone 1 g daily during pregnancy and postpartum. Information obtained in this website are not exhaustive and do not cover all diseases, ailments, physical conditions or their treatment. Br J Clin Pharmacol. Letter. [15]Three breastfed infants had steady-state serum carbamazepine levels measured during maternal therapy. Benefits of Bactrim while Breastfeeding: A number of bacterial infections can be treated with the help of Bactrim in nursing mothers. The infant/maternal serum concentration ratio ranged from 0 to 0.7 and the epoxide ratio ranged from 0 to 3. The epoxide metabolite was not measured. The late hepatic abnormalities were considered to be probably caused by carbamazepine in breastmilk. Some other anticonvulsants (e.g., phenytoin, carbamazepine) stimulate the metabolism of other drugs including anticonvulsants, whereas others (e.g., valproic acid) inhibit the metabolism of other drugs. Lancet 1987;330:272-3. Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: A prospective cohort study on children of women with epilepsy. Carbamazepine: placental transport, tissue concentrations in foetus and newborn, and level in milk. Antiepileptic drug exposure in infants of breastfeeding mothers with epilepsy. [8] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.1. Partial formula feeding did not resolve the problem, but cessation of breastfeeding resolved the symptoms rapidly. [6]Four mothers taking carbamazepine monotherapy in an average dosage of 10.95 mg/kg daily had average milk levels of 1.78 mg/L at various times during the first month postpartum. The mother’s dosages and corresponding infant serum levels are as follows: 10.3 mg/kg daily and 0.5 mg/L at 5 days of age; 22 mg/kg daily and 1 mg/L at 28 days of age; and, 10.6 mg/kg and 4.7 mg/L at 28 days of age. Carbamazepine: placental transport, tissue concentrations in foetus and newborn, and level in milk. Lopes BR, Barreiro JC, Baraldi PT, et al. Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. 2014;10:11-2. Median infant blood levels of carbamazepine were 5.7% (range 3.7 to 8.4%) and median carbamazepine epoxide infant blood levels were 5.4% (range 0.9 to 9.6%) of their mothers’ blood levels. Ther Drug Monit. Site users seeking medical advice about their specific situation should consult with their own physician. [The perinatal pharmacokinetics of anticonvulsant drugs]. All rights reserved, USA and worldwide. Drowsiness due to clemastine transmitted in breast milk. Carbamazepine epoxide was measured in the milk of 6 of the women and averaged 1.5 mg/L. Nat Rev Neurol 2014;10:11-2. 16. [8]A breastfed infant whose mother was taking primidone 375 mg, phenobarbital 90 mg, and carbamazepine 800 mg daily did well despite a saliva phenobarbital level of 3.4 mg/L. 1992;26:1563-5. [11]Breastmilk levels of carbamazepine and its metabolite were measured in one milk sample taken 8 hours after a dose of 200 mg of carbamazepine. Froescher W, Eichelbaum M, Niesen M et al. [15] Fifty-four breastfed infants whose mothers were taking carbamazepine had serum samples taken between 6 and 10 days postpartum. Wisner KL, Perel JM. [7]Weak sucking occurred in 1 of 15 breastfed infants whose mothers were on carbamazepine monotherapy, but a causal relationship could not be confirmed.