The clinical dose of carboplatin as an i.v. Elsevier Science Epub 2019 Mar 7. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780323244855001285URL: https://www.sciencedirect.com/science/article/pii/B9780702028588500178URL: https://www.sciencedirect.com/science/article/pii/B9781437706604000284URL: https://www.sciencedirect.com/science/article/pii/B9781437723625000244URL: https://www.sciencedirect.com/science/article/pii/B9780444521668500303URL: https://www.sciencedirect.com/science/article/pii/B9780128000779000542URL: https://www.sciencedirect.com/science/article/pii/B0123708796004099URL: https://www.sciencedirect.com/science/article/pii/B9780323523578000445URL: https://www.sciencedirect.com/science/article/pii/B9780323357623000573URL: https://www.sciencedirect.com/science/article/pii/B9781416045724000108Saunders Handbook of Veterinary Drugs (Fourth Edition)Small Animal Clinical Pharmacology (Second Edition)Withrow and MacEwen's Small Animal Clinical Oncology (Fifth Edition)Castration Resistant Prostate Cancer: Role of ChemotherapyFrontline Systemic Therapy Options in Nonsmall Cell Lung CancerPharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic MalignanciesTOXICITIES OF CHEMOTHERAPY FOR GENITOURINARY MALIGNANCIESScienceDirect ® is a registered trademark of Elsevier B.V. Six anuric patients with chronic renal failure were given two 20mg doses of buspirone, the first 2 days before haemodialysis (between dialyses) an … Cisplatin Nausea and vomiting are generally mild, and respond to the 5-HTSeveral studies have compared the efficacy of cisplatin with carboplatin in the management of advanced NSCLC. Synonyms of this drug are paraplatin and others.Myelosuppression (particularly thrombocytopenia) is dose-limiting. Like cisplatin, carboplatin also reacts with DNA to form both internal and external cross-bonds. This site needs JavaScript to work properly. Neutrophil and platelet nadirs generally occur 2 to 3 weeks after administration.Administration of cisplatin to cats induces a fatal pulmonary edema. Epub 2019 Jun 20.Yamashita K, Tsunoda S, Gunji S, Murakami T, Suzuki T, Tabata Y, Sakai Y.Surg Today. Please enable it to take advantage of the complete set of features! doi: 10.1002/14651858.CD001418.Crit Rev Oncol Hematol. 2020 Aug 7;10:1402. doi: 10.3389/fonc.2020.01402. Rosell et al.A meta-analysis using data from eight trials demonstrated that cisplatin-based chemotherapy offered a significantly higher objective response rate compared with carboplatin-based chemotherapy (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.15 to 1.61; In previously untreated adults, the AUC can be estimated at 7 when carboplatin is used alone and 4.5 when used in combination. Bone marrow suppression is the dose-limiting toxicity of carboplatin injection. 2019 Sep;49(9):785-794. doi: 10.1007/s00595-019-01792-y. Name must be less than 100 characters 12 patients with mild to moderate impairment of renal function and 12 healthy subjects each received 20mg buspirone as a single dose in this acute study. PARAPLATIN® (carboplatin) Injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Thrombocytopenia with platelet counts below 50,000/mm³ occurs in 25% of the patients (35% of pretreated ovarian cancer patients); neutropenia with granulocyte counts below 1,000/mm³ occurs in 16% of the patients (21% of pretreated ovarian cancer patients); leukopenia with … 2019 Aug;95:127-135. doi: 10.1016/j.oraloncology.2019.06.016. eCollection 2020.Romano A, Capozza MA, Mastrangelo S, Maurizi P, Triarico S, Rolesi R, Attinà G, Fetoni AR, Ruggiero A.Cancers (Basel). The carboplatin-docetaxel arm had a more favourable toxicity profile and a significant number of patients withdrew from the cisplatin-docetaxel doublet due to grade 3–4 emesis (Greco et al., 2000).