There are implications that make the decision to consume cannabis products and alcohol together something to carefully consider:Perhaps one of the most common combinations for CBD users is the consumption of caffeine (via coffee or tea) alongside CBD. If your doctor has warned you about consuming grapefruit with any of your medications, it is a strong sign that you may see similar recommendations for CBD oil.As we mentioned above, the number of drugs processed by Cytochrome P450 is large. All trademarks and copyrights are the property of their respective owners and are not affiliated with nor do they endorse this product. For example, THC induces CYP1A2, reducing the levels of drugs metabolized by this enzyme. CBD Oil Interactions – The Bottom Line. This is especially true if you are taking a medication that is metabolized by the liver or warns about taking it with grapefruit. CBD, however, turns out to be a more potent inhibitor than compounds in grapefruit like bergapten (the strongest of several grapefruit components that inhibit this system). On the flip side, these interactions can be positive. This means that consuming CBD and caffeine together lead to a slower rate of caffeine processing through the body, resulting in a more drawn-out caffeine effect.The interaction between these two substances is being anecdotally documented as the rise of CBD and other compounds in hemp oil may interact with a wide range of drugs. Researchers have published a list of 57 medications that may interact with cannabinoid products, including cannabis and cannabidiol (CBD) oil. CBD is very well-tolerated in most people. In 2013, the results of a As well as the more traditional means of using cannabis, such as smoking, there is growing interest in CBD oil, which contains only CBD and not the psychoactive component of cannabis, Although more people are consuming cannabinoid products, there is limited information on how these products may interact with other medications.To combat this knowledge gap, researchers from Penn State College of Medicine in Hershey, PA, have published a list of prescription medications that may not work as intended when people take them alongside medical cannabinoids, CBD oil, or medical or recreational cannabis.The growing number of cannabis-derived products on the market can deliver a variable concentration of the cannabinoids THC and CBD. CBD oil derived from hemp was legalized throughout the U.S. in 2018. We believe that everyone has the potential to benefit from daily use of phytocannabinoid-rich products. The list includes commonly prescribed medications, such as anticoagulants, pain relievers, and birth control pills.The issue of legalizing cannabis is a divisive one. Above, we describe CBD is metabolism by CYP3A4 and CYP2C19. This small margin makes interactions that may increase the action of these drugs a medical concern.The researchers have also published a longer list of The possible side effects of mixing cannabinoids with the prescribed drugs on the study authors’ list include dizziness, confusion, and sedation, but the authors also warn of more serious issues, including effects on the heart.They say that changes to blood pressure and heart rhythm may occur if people take cannabinoids with medications that have similar effects on the cardiovascular system.They recommend that doctors take account of a person’s use of cannabinoids when prescribing drugs and encourage their patients to be upfront about their cannabinoid intake — medical or otherwise.“The drug-drug interaction information from medical cannabinoids may be useful as medical professionals consider the potential impact of over-the-counter or illicit cannabinoid products.” The authors also note that the likelihood of interactions depends on the individual, based on their gender, age, genetics, and state of health. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.© 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Similar to the drugs we discussed above, alcohol depends on specific metabolic pathways in the body to be processed.Specifically, the substance relies on the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) to be processed under normal conditions.