Treatment should only be given if clearly needed.Cefpodoxime is excreted in human milk. We comply with the HONcode standard for trustworthy health information - These results demonstrated that concentrations of cefpodoxime exceeded the MICFollowing a single, oral 200 mg Cefpodoxime Proxetil film-coated tablet, the mean maximum cefpodoxime concentration in lung tissue averaged 0.63 mcg/g at 3 hours post-dosing, 0.52 mcg/g at 6 hours post-dosing, and 0.19 mcg/g at 12 hours post-dosing. No untoward effects on fertility or reproduction were noted when 100 mg/kg/day or less (2 times the human dose based on mg/m2) was administered orally to rats.Cefpodoxime Proxetil was neither teratogenic nor embryocidal when administered to rats during organogenesis at doses up to 100 mg/kg/day (2 times the human dose based on mg/m2) or to rabbits at doses up to 30 mg/kg/day (1 to 2 times the human dose based on mg/mThere are, however, no adequate and well-controlled studies of Cefpodoxime Proxetil use in pregnant women. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. 6. There were no deaths or permanent disabilities thought related to drug toxicity in these studies.Adverse events thought possibly or probably related to cefpodoxime in single-dose clinical trials conducted in the United States were:Nausea                                                         1.4%Diarrhea                                                       1.2%Significant laboratory changes that have been reported in adult and pediatric patients in clinical trials of Cefpodoxime Proxetil, without regard to drug relationship, were:Most of these abnormalities were transient and not clinically significant.The following serious adverse experiences have been reported: allergic reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and serum sickness-like reactions, pseudomembranous colitis, bloody diarrhea with abdominal pain, ulcerative colitis, rectorrhagia with hypotension, anaphylactic shock, acute liver injury, in utero exposure with miscarriage, purpuric nephritis, pulmonary infiltrate with eosinophilia, and eyelid dermatitis.One death was attributed to pseudomembranous colitis and disseminated intravascular coagulation.In addition to the adverse reactions listed above which have been observed in patients treated with Cefpodoxime Proxetil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics:Adverse Reactions and Abnormal Laboratory Tests: Renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, serum sickness-like reaction, hemorrhage, agranulocytosis, and pancytopenia.Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. 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