Am J Respir Crit Care Med 1999; 160:883–6 Phipps PR, Starritt E, Caterson I, Grunstein RR: Association of serum leptin with hypoventilation in human obesity. The French Congenital Central Hypoventilation Syndrome Registry: general data, phenotype, and genotype. Trang H, Dehan M, Beaufils F, et al. – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3f1682-ZDRlM Am Rev Respir Dis 1980; 122:747–54 Robinson TD, Freiberg DB, Regnis JA, Young IH: The role of hypoventilation and ventilation-perfusion redistribution in oxygen-induced hypercapnia during acute exacerbations of chronic obstructive pulmonary disease. Effects of Positive Airway Pressure Therapy on Sleep ParametersLong-term benefits of PAP include an improvement in gas exchange, lung volumes, and central respiratory drive to carbon dioxide. ANESTHESIOLOGY 2009;110:218–30 Rennotte MT, Baele P, Aubert G, Rodenstein DO: Nasal continuous positive airway pressure in the perioperative management of patients with obstructive sleep apnea submitted to surgery. The prevalence of OHS is estimated to be 0.15–0.3% in the general populationPerioperative management begins with a high index of suspicion for OHS in the morbidly obese patient. This site uses cookies. J Appl Physiol 2006; 100:1733–41 Borel J, Roux-Lombard P, Tamisier R, Arnaud C, Monneret D, Arnol N, Baguet JP, Levy P, Pepin JL: Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. the neonatal period, and deficient cognitive skills in school-aged patients. Am J Respir Crit Care Med 2000; 161:1524–9 Wijesinghe M, Williams M, Perrin K, Weatherall M, Beasley R: The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation: A randomized, crossover, clinical study. Preschool patients with CCHS fell significantly below the normative mean of 100 on Thorax 2002; 57:75–6 Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, Kuriyama T: Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Eur Respir J 1999; 14:179–84 Sin DD, Fitzgerald F, Parker JD, Newton GE, Logan AG, Floras JS, Bradley TD: Relationship of systolic BP to obstructive sleep apnea in patients with heart failure. Suggested algorithm for preoperative evaluation and management of the suspected OHS patient. A chest x-ray showing cardiomegaly or abnormal pulmonary vascularity suggests undiagnosed heart failure and pulmonary hypertension. Clinical features of the patient with obesity hypoventilation syndrome.Patients with OHS display increased upper airway resistance in both the sitting and supine position in comparison with obese individuals with eucapnia.Simple obesity impairs respiratory mechanics leading to reduced lung volumes, decreased chest wall compliance, increased respiratory resistance, and increased work of breathing.Studies on OHS respiratory mechanics reveal an excessive load imposed on the respiratory system. Am J Med 2009; 122:535–42 Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K: Bariatric surgery: A systematic review and meta-analysis. Idiopathic congenital central hypoventilation syndrome: diagnosis and management. Screening questionnaires such as the validated STOP-Bang questionnaire can identify patients at high risk of OSA. Obesity hypoventilation syndrome. Circulation 1981; 64:477–82 Arzt M, Young T, Finn L, Skatrud JB, Bradley TD: Association of sleep-disordered breathing and the occurrence of stroke. We hypothesized Respiratory depression (hypoventilation) is a breathing disorder characterized by slow and ineffective breathing. In a cohort of obese patients with OSA referred to a sleep laboratory, a serum bicarbonate threshold of 27 mEq/l was suggested as a screening test (sensitivity 92%; specificity 50%) for obesity hypoventilation syndrome.The three main challenges in OHS are OSA, obesity, and hypoventilation (hypercapnia and hypoxemia).