Let your doctor know if this becomes a problem.Use this medication regularly to get the most benefit from it. Call your doctor for medical advice about side effects. See also Precautions section.Tell your doctor right away if you have any serious side effects, including:Get medical help right away if you have any very serious side effects, including:Abruptly stopping or reducing the dose of this medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Carbidopa and levodopa combination is used to treat Parkinson's disease, sometimes called shaking palsy or paralysis agitans. Make an Appointment; Change an Appointment; Cancel an Appointment; Find a Doctor; Find Directions; Charges & Payment; Admissions; Visiting Policy and Registration; Discharge Time & Procedures; Outpatient Consultation; Post-Hospitalisation Care & Programme; Facilities & Amenities. If these effects occur, contact your doctor for possible dose adjustments that may help to lessen this effect.Do not stop taking this medication without consulting your doctor. However, certain MAO inhibitors (rasagiline, safinamide, selegiline) may be used with careful monitoring by your doctor. This is not a complete list of side effects and others may occur. Copyright © 2020 National University Health System. This sleep effect may occur anytime during treatment with this medication even if you have used this medication for a long time. Doing so can release all of the drug at once, increasing the risk of side effects. Make sure you understand your dosing schedule and follow it closely.Some patients may experience a "wearing-off" (worsening of symptoms) before the next dose is due. Otherwise, call a poison control center right away. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Ask your doctor if you should have regular skin exams.If you miss a dose, take it as soon as you remember. Always ask your health care professional for complete information about this product and your specific health needs. Tell your doctor promptly if you have a mole that gets bigger or looks different, or if you have other unusual skin changes. For Parkinson's Disease: “It stops tremors in its tracks I know bc I have Parkinson’s like symptoms and about 4 years ago I had started the tremors or shakes and my ex wife now made an appointment for me with a neurologist and he had prescribed me sinemet 25/100s three times daily but I still had a little tremor in my hands so he added one more pill per day to my regimen … My neuro has confirmed that my deterioration has been slow. Consult your pharmacist or local waste disposal company.HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. If it is near the time of the next dose, skip the missed dose. Discuss the risks and benefits with your doctor.Levodopa passes into breast milk in small amounts and may affect how much milk you make. (See also Side Effects section. Your medication may look different. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of:This drug may make you dizzy or drowsy. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include:Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:This is not a complete list of possible side effects. If you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities until you have discussed this effect with your doctor. In some cases, sleep occurred without any feelings of drowsiness beforehand. US residents can call their local poison control center at 1-800-222-1222. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy. Sinemet 10010; Sinemet 10025; Sinemet 25025; Sinemet CR 10025; Sinemet CR 20050; Descriptions.